Methylthioadenosine nucleosidase

From Wikipedia, the free encyclopedia

In enzymology, a methylthioadenosine nucleosidase (EC 3.2.2.16) is an enzyme that catalyzes the chemical reaction

S-methyl-5'-thioadenosine + H₂O S-methyl-5-thio-D-ribose + adenine

Thus, the two substrates of this enzyme are S-methyl-5'-thioadenosine and H₂O, whereas its two products are S-methyl-5-thio-D-ribose and adenine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is S-methyl-5'-thioadenosine adeninehyrolase. Other names in common use include 5'-methylthioadenosine nucleosidase, MTA nucleosidase, MeSAdo nucleosidase, and methylthioadenosine methylthioribohydrolase. This enzyme participates in urea cycle and metabolism of amino groups and methionine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1NC1, 1NC3, 1Y6Q, 1Y6R, 1ZOS, and 2H8G.

[edit] References

• IUBMB entry for 3.2.2.16
• BRENDA references for 3.2.2.16 (Recommended.)
• PubMed references for 3.2.2.16
• PubMed Central references for 3.2.2.16
• Google Scholar references for 3.2.2.16
• Guranowski AB, Chiang PK, Cantoni GL (1981). "5'-Methylthioadenosine nucleosidase. Purification and characterization of the enzyme from Lupinus luteus seeds". Eur. J. Biochem. 114: 293–9. PMID 6783408. 

[edit] External links

The CAS registry number for this enzyme class is 50812-28-7.

• IUBMB entry for 3.2.2.16

• KEGG entry for 3.2.2.16

• BRENDA entry for 3.2.2.16

• NiceZyme view of 3.2.2.16

• EC2PDB: PDB structures for 3.2.2.16

• PRIAM entry for 3.2.2.16

• PUMA2 entry for 3.2.2.16

• IntEnz: Integrated Enzyme entry for 3.2.2.16

• MetaCyc entry for 3.2.2.16

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008930: methylthioadenosine nucleosidase

• AMIGO entry for GO code 0008930: methylthioadenosine nucleosidase