Methylphenobarbital

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Methylphenobarbital
Systematic (IUPAC) name
5-phenyl-5-ethyl-
3-methylbarbituric acid
Identifiers
CAS number 115-38-8
ATC code N03AA01
PubChem 8271
DrugBank APRD00047
Chemical data
Formula C13H14N2O3 
Mol. mass 246.3
Pharmacokinetic data
Bioavailability  ?
Protein binding 70-76%
Metabolism Hepatic
Half life 34 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

Schedule IV(US)

Routes  ?

Methylphenobarbital, also known as mephobarbital, (marketed in the US under the brand name Mebaral by Ovation) is a drug which is a barbiturate derivative.

Methylphenobarbital is used as a sedative, anxiolytic and anticonvulsant. It is the N-methylated analogue of phenobarbital, and has similar indications, therapeutic value, and tolerability.

[edit] Approval History

  • 1935 Mebaral was introduced by Winthrop Pharmaceuticals.
  • 2001 Methylphenobarbital discontinued in the UK.
  • 2003 Mebaral acquired by Ovation Pharmaceuticals (specialty pharmaceutical company who acquire underpromoted branded pharmaceutical products).

[edit] Overdose symptoms

Symptoms of overdose of metharbital include confusion, decrease in or loss of reflexes, somnolence, pyrexia, irritability, hypothermia, poor judgment, shortness of breath or slow/troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness

[edit] References

  • The Treatment of Epilepsy 2nd Ed by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. ISBN 0-632-06046-8


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