Methylglyoxal synthase

From Wikipedia, the free encyclopedia

In enzymology, a methylglyoxal synthase (EC 4.2.3.3) is an enzyme that catalyzes the chemical reaction

glycerone phosphate $\rightleftharpoons$ methylglyoxal + phosphate

Hence, this enzyme has one substrate, glycerone phosphate, and two products, methylglyoxal and phosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is glycerone-phosphate phosphate-lyase (methylglyoxal-forming). Other names in common use include methylglyoxal synthetase, and glycerone-phosphate phospho-lyase. This enzyme participates in pyruvate metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1B93, 1EGH, 1IK4, 1S89, 1S8A, 1VMD, and 1WO8.

[edit] References

IUBMB entry for 4.2.3.3
BRENDA references for 4.2.3.3 (Recommended.)
PubMed references for 4.2.3.3
PubMed Central references for 4.2.3.3
Google Scholar references for 4.2.3.3
Cooper RA, Anderson A (1970). "The formation and catabolism of methylglyoxal during glycolysis in Escherichia coli". FEBS. Lett. 11: 273–276. doi:10.1016/0014-5793(70)80546-4. PMID 11945504.
Hopper DJ, Cooper RA (1971). "The regulation of Escherichia coli methylglyoxal synthase; a new control site in glycolysis?". FEBS. Lett. 13: 213–216. doi:10.1016/0014-5793(71)80538-0. PMID 11945670.
Ray S, Ray M (1981). "Isolation of methylglyoxal synthase from goat liver". J. Biol. Chem. 256: 6230–3. PMID 7240200.