Methylglutamate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a methylglutamate dehydrogenase (EC 1.5.99.5) is an enzyme that catalyzes the chemical reaction

N-methyl-L-glutamate + acceptor + H₂O L-glutamate + formaldehyde + reduced acceptor

The 3 substrates of this enzyme are N-methyl-L-glutamate, acceptor, and H₂O, whereas its 3 products are L-glutamate, formaldehyde, and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is N-methyl-L-glutamate:acceptor oxidoreductase (demethylating). Other names in common use include N-methylglutamate dehydrogenase, and N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating). This enzyme participates in methane metabolism.

[edit] References

• IUBMB entry for 1.5.99.5
• BRENDA references for 1.5.99.5 (Recommended.)
• PubMed references for 1.5.99.5
• PubMed Central references for 1.5.99.5
• Google Scholar references for 1.5.99.5
• Hersh LB, Stark MJ, Worthen S, Fiero MK (1972). "N-methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme". Arch. Biochem. Biophys. 150: 219–26. doi:10.1016/0003-9861(72)90029-X. PMID 5028076. 

[edit] External links

The CAS registry number for this enzyme class is 37217-26-8.

• IUBMB entry for 1.5.99.5

• KEGG entry for 1.5.99.5

• BRENDA entry for 1.5.99.5

• NiceZyme view of 1.5.99.5

• EC2PDB: PDB structures for 1.5.99.5

• PRIAM entry for 1.5.99.5

• PUMA2 entry for 1.5.99.5

• IntEnz: Integrated Enzyme entry for 1.5.99.5

• MetaCyc entry for 1.5.99.5

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050099: methylglutamate dehydrogenase

• AMIGO entry for GO code 0050099: methylglutamate dehydrogenase