Methylenetetrahydromethanopterin dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a methylenetetrahydromethanopterin dehydrogenase (EC 1.5.99.9) is an enzyme that catalyzes the chemical reaction

5,10-methylenetetrahydromethanopterin + coenzyme F₄20 $\rightleftharpoons$ 5,10-methenyltetrahydromethanopterin + reduced coenzyme F₄20

Thus, the two substrates of this enzyme are 5,10-methylenetetrahydromethanopterin and coenzyme F420, whereas its two products are 5,10-methenyltetrahydromethanopterin and reduced coenzyme F420.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is 5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase. Other names in common use include N5,N10-methylenetetrahydromethanopterin dehydrogenase, and 5,10-methylenetetrahydromethanopterin dehydrogenase. This enzyme participates in folate biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1QV9, 1U6I, 1U6J, and 1U6K.

[edit] References

IUBMB entry for 1.5.99.9
BRENDA references for 1.5.99.9 (Recommended.)
PubMed references for 1.5.99.9
PubMed Central references for 1.5.99.9
Google Scholar references for 1.5.99.9
Hartzell PL, Zvilius G, Escalante-Semerena JC, Donnelly MI (1985). "Coenzyme F420 dependence of the methylenetetrahydromethanopterin dehydrogenase of Methanobacterium thermoautotrophicum". Biochem. Biophys. Res. Commun. 133: 884–90. doi:10.1016/0006-291X(85)91218-5. PMID 4084309.
GD (1991). "Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri". Biochim. Biophys. Acta. 1079: 293–302. PMID 1911853.