Methylenetetrahydrofolate dehydrogenase (NAD+)

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In enzymology, a methylenetetrahydrofolate dehydrogenase (NAD+) (EC 1.5.1.15) is an enzyme that catalyzes the chemical reaction

5,10-methylenetetrahydrofolate + NAD+ \rightleftharpoons 5,10-methenyltetrahydrofolate + NADH + H+

Thus, the two substrates of this enzyme are 5,10-methylenetetrahydrofolate and NAD+, whereas its 3 products are 5,10-methenyltetrahydrofolate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase. This enzyme is also called methylenetetrahydrofolate dehydrogenase (NAD+). This enzyme participates in one carbon pool by folate.

Contents

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1EDZ and 1EE9.

[edit] References

[edit] External links

The CAS registry number for this enzyme class is 82062-90-6.

[edit] Gene Ontology (GO) codes