Methyl-CpG-binding domain protein 2

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Methyl-CpG binding domain protein 2
Identifiers
Symbol(s) MBD2; DKFZp586O0821; DMTase; NY-CO-41
External IDs OMIM: 603547 MGI: 1333813 HomoloGene: 2918
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8932 17191
Ensembl ENSG00000134046 ENSMUSG00000024513
Uniprot Q9UBB5 Q9Z2E1
Refseq NM_003927 (mRNA)
NP_003918 (protein)		 XM_001000950 (mRNA)
XP_001000950 (protein)
Location Chr 18: 49.93 - 50.01 Mb Chr 18: 70.69 - 70.75 Mb
Pubmed search [1] [2]

Methyl-CpG binding domain protein 2, also known as MBD2, is a human gene.

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.[1]

[edit] References

  1. ^ Entrez Gene: MBD2 methyl-CpG binding domain protein 2.

[edit] Further reading

  • Scanlan MJ, Chen YT, Williamson B, et al. (1998). "Characterization of human colon cancer antigens recognized by autologous antibodies.". Int. J. Cancer 76 (5): 652-8. PMID 9610721. 
  • Hendrich B, Bird A (1998). "Identification and characterization of a family of mammalian methyl-CpG binding proteins.". Mol. Cell. Biol. 18 (11): 6538-47. PMID 9774669. 
  • Zhang Y, LeRoy G, Seelig HP, et al. (1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.". Cell 95 (2): 279-89. PMID 9790534. 
  • Tong JK, Hassig CA, Schnitzler GR, et al. (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.". Nature 395 (6705): 917-21. doi:10.1038/27699. PMID 9804427. 
  • Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M (1999). "A mammalian protein with specific demethylase activity for mCpG DNA.". Nature 397 (6720): 579-83. doi:10.1038/17533. PMID 10050851. 
  • Hendrich B, Abbott C, McQueen H, et al. (1999). "Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes.". Mamm. Genome 10 (9): 906-12. PMID 10441743. 
  • Zhang Y, Ng HH, Erdjument-Bromage H, et al. (1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.". Genes Dev. 13 (15): 1924-35. PMID 10444591. 
  • Ng HH, Zhang Y, Hendrich B, et al. (1999). "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex.". Nat. Genet. 23 (1): 58-61. doi:10.1038/12659. PMID 10471499. 
  • Tatematsu KI, Yamazaki T, Ishikawa F (2000). "MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase.". Genes Cells 5 (8): 677-88. PMID 10947852. 
  • Boeke J, Ammerpohl O, Kegel S, et al. (2001). "The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A.". J. Biol. Chem. 275 (45): 34963-7. doi:10.1074/jbc.M005929200. PMID 10950960. 
  • Humphrey GW, Wang Y, Russanova VR, et al. (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.". J. Biol. Chem. 276 (9): 6817-24. doi:10.1074/jbc.M007372200. PMID 11102443. 
  • Feng Q, Zhang Y (2001). "The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes.". Genes Dev. 15 (7): 827-32. doi:10.1101/gad.876201. PMID 11297506. 
  • Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y (2001). "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2.". J. Biol. Chem. 276 (46): 42632-8. doi:10.1074/jbc.M107048200. PMID 11553631. 
  • Müller-Tidow C, Kügler K, Diederichs S, et al. (2001). "Loss of expression of HDAC-recruiting methyl-CpG-binding domain proteins in human cancer.". Br. J. Cancer 85 (8): 1168-74. doi:10.1054/bjoc.2001.2041. PMID 11710831. 
  • Feng Q, Cao R, Xia L, et al. (2002). "Identification and functional characterization of the p66/p68 components of the MeCP1 complex.". Mol. Cell. Biol. 22 (2): 536-46. PMID 11756549. 
  • Bakker J, Lin X, Nelson WG (2002). "Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells.". J. Biol. Chem. 277 (25): 22573-80. doi:10.1074/jbc.M203009200. PMID 11960994. 
  • Saito M, Ishikawa F (2002). "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.". J. Biol. Chem. 277 (38): 35434-9. doi:10.1074/jbc.M203455200. PMID 12124384. 
  • Detich N, Theberge J, Szyf M (2002). "Promoter-specific activation and demethylation by MBD2/demethylase.". J. Biol. Chem. 277 (39): 35791-4. doi:10.1074/jbc.C200408200. PMID 12177048. 
  • Brackertz M, Boeke J, Zhang R, Renkawitz R (2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3.". J. Biol. Chem. 277 (43): 40958-66. doi:10.1074/jbc.M207467200. PMID 12183469. 
  • Krithivas A, Fujimuro M, Weidner M, et al. (2002). "Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes.". J. Virol. 76 (22): 11596-604. PMID 12388720. 
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