Methionine S-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a methionine S-methyltransferase (EC 2.1.1.12) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + L-methionine S-adenosyl-L-homocysteine + S-methyl-L-methionine

Thus, the two substrates of this enzyme are S-adenosyl methionine and L-methionine, whereas its two products are S-adenosylhomocysteine and S-methyl-L-methionine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:L-methionine S-methyltransferase. Other names in common use include S-adenosyl methionine:methionine methyl transferase, methionine methyltransferase, S-adenosylmethionine transmethylase, and S-adenosylmethionine-methionine methyltransferase. This enzyme participates in selenoamino acid metabolism. It has 2 cofactors: manganese, and zinc.

[edit] References

• IUBMB entry for 2.1.1.12
• BRENDA references for 2.1.1.12 (Recommended.)
• PubMed references for 2.1.1.12
• PubMed Central references for 2.1.1.12
• Google Scholar references for 2.1.1.12
• Karr D, Tweto J, Albersheim P (1967). "S-adenosyl methionine: methionine methyl transferase from wheat germ". Arch. Biochem. Biophys. 121: 732–8. doi:10.1016/0003-9861(67)90061-6. PMID 6078098. 

[edit] External links

The CAS registry number for this enzyme class is 9027-77-4.

• IUBMB entry for 2.1.1.12

• KEGG entry for 2.1.1.12

• BRENDA entry for 2.1.1.12

• NiceZyme view of 2.1.1.12

• EC2PDB: PDB structures for 2.1.1.12

• PRIAM entry for 2.1.1.12

• PUMA2 entry for 2.1.1.12

• IntEnz: Integrated Enzyme entry for 2.1.1.12

• MetaCyc entry for 2.1.1.12

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0030732: methionine S-methyltransferase

• AMIGO entry for GO code 0030732: methionine S-methyltransferase