Methenyltetrahydromethanopterin cyclohydrolase

From Wikipedia, the free encyclopedia

In enzymology, a methenyltetrahydromethanopterin cyclohydrolase (EC 3.5.4.27) is an enzyme that catalyzes the chemical reaction

5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H₂O 5-formyl-5,6,7,8-tetrahydromethanopterin

Thus, the two substrates of this enzyme are 5,10-methenyl-5,6,7,8-tetrahydromethanopterin and H₂O, whereas its product is 5-formyl-5,6,7,8-tetrahydromethanopterin.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing). Other names in common use include 5,10-methenyltetrahydromethanopterin cyclohydrolase, N5,N10-methenyltetrahydromethanopterin cyclohydrolase, and methenyl-H4MPT cyclohydrolase. This enzyme participates in folate biosynthesis.

[edit] References

• IUBMB entry for 3.5.4.27
• BRENDA references for 3.5.4.27 (Recommended.)
• PubMed references for 3.5.4.27
• PubMed Central references for 3.5.4.27
• Google Scholar references for 3.5.4.27
• Donnelly MI, Escalante-Semerena JC, Rinehart KL Jr, Wolfe RS (1985). "Methenyl-tetrahydromethanopterin cyclohydrolase in cell extracts of Methanobacterium". Arch. Biochem. Biophys. 242: 430–9. doi:10.1016/0003-9861(85)90227-9. PMID 4062290. 

[edit] External links

The CAS registry number for this enzyme class is 99533-50-3.

• IUBMB entry for 3.5.4.27

• KEGG entry for 3.5.4.27

• BRENDA entry for 3.5.4.27

• NiceZyme view of 3.5.4.27

• EC2PDB: PDB structures for 3.5.4.27

• PRIAM entry for 3.5.4.27

• PUMA2 entry for 3.5.4.27

• IntEnz: Integrated Enzyme entry for 3.5.4.27

• MetaCyc entry for 3.5.4.27

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018759: methenyltetrahydromethanopterin cyclohydrolase

• AMIGO entry for GO code 0018759: methenyltetrahydromethanopterin cyclohydrolase