Methenyltetrahydrofolate cyclohydrolase

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In enzymology, a methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) is an enzyme that catalyzes the chemical reaction

5,10-methenyltetrahydrofolate + H₂O $\rightleftharpoons$ 10-formyltetrahydrofolate

Thus, the two substrates of this enzyme are 5,10-methenyltetrahydrofolate and H₂O, whereas its product is 10-formyltetrahydrofolate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing). Other names in common use include Citrovorum factor cyclodehydrase, cyclohydrolase, and formyl-methenyl-methylenetetrahydrofolate synthetase (combined). This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1A4I, 1DIA, 1DIB, 1DIG, 2C2X, and 2C2Y.

[edit] References

IUBMB entry for 3.5.4.9
BRENDA references for 3.5.4.9 (Recommended.)
PubMed references for 3.5.4.9
PubMed Central references for 3.5.4.9
Google Scholar references for 3.5.4.9
Rabinowitz JC and Pricer WE (1956). "The enzymatic synthesis of N10-formyltetrahydrofolic acid and its role in ATP formation during formiminoglycine degradation". J. Am. Chem. Soc. 78: 4176–4178. doi:10.1021/ja01597a094.
Tabor H and Wyngarden L (1959). "The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid". J. Biol. Chem. 234: 1830–1849.