Metastasis suppressor

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A metastasis suppressor is a protein that acts to slow or prevent metastases (secondary tumors) from spreading in the body of an organism with cancer.[1] These proteins are different from ones that act to suppress tumor growth.[2] Genes for about a dozen such proteins are known in humans and other animals, including BRMS1, CRSP3, DRG1, KAI1, KISS1, NM23, and various TIMPs.[3] [4]


[edit] References

  1. ^ Sobel, ME. 1990. Metastasis suppressor genes. Journal of the National Cancer Institute 82: 267-276.
  2. ^ Yoshida, BA, Sokoloff, MM, Welch, DR, Rinker-Schaeffer CW. 2000. Metastasis-suppressor genes: a review and perspective on an emerging field. Journal of the National Cancer Institute 92: 1717-1730.
  3. ^ Shevde, LA, Welch, DR. 2003. Metastasis suppressor pathways - an evolving paradigm. Cancer Letters, 198: 1-20.
  4. ^ Jackson (Ed.), Paul (2007). New Developments in Metastasis Suppressor Research. Nova Science Pub Inc. ISBN 160021603X. 
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