Metallothionein 2A

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Metallothionein 2A
PDB rendering based on 1mhu.
Available structures: 1mhu, 1mrb, 1mrt, 2mhu
Identifiers
Symbol(s) MT2A; MT2
External IDs OMIM: 156360 MGI: 97172 HomoloGene: 48388
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4502 17750
Ensembl ENSG00000125148 ENSMUSG00000031762
Uniprot P02795 P02798
Refseq NM_005953 (mRNA)
NP_005944 (protein)		 NM_008630 (mRNA)
NP_032656 (protein)
Location Chr 16: 55.2 - 55.2 Mb Chr 8: 97.06 - 97.06 Mb
Pubmed search [1] [2]

Metallothionein 2A, also known as MT2A, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: MT2A metallothionein 2A.

[edit] Further reading

  • Kissling MM, Kägi HR (1977). "Primary structure of human hepatic metallothionein.". FEBS Lett. 82 (2): 247-50. PMID 913597. 
  • Yamazaki S, Nakanishi M, Hamamoto T, et al. (1993). "Expression of human metallothionein-II fusion protein in Escherichia coli.". Biochem. Int. 28 (3): 451-60. PMID 1339282. 
  • Messerle BA, Schäffer A, Vasák M, et al. (1992). "Comparison of the solution conformations of human [Zn7]-metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy.". J. Mol. Biol. 225 (2): 433-43. PMID 1593628. 
  • Zafarullah M, Martel-Pelletier J, Cloutier JM, et al. (1992). "Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte.". FEBS Lett. 306 (2-3): 169-72. PMID 1633872. 
  • Messerle BA, Schäffer A, Vasák M, et al. (1990). "Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy.". J. Mol. Biol. 214 (3): 765-79. PMID 2388267. 
  • Duguid JR, Bohmont CW, Liu NG, Tourtellotte WW (1989). "Changes in brain gene expression shared by scrapie and Alzheimer disease.". Proc. Natl. Acad. Sci. U.S.A. 86 (18): 7260-4. PMID 2780570. 
  • Karin M, Haslinger A, Heguy A, et al. (1987). "Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity.". Mol. Cell. Biol. 7 (2): 606-13. PMID 3821726. 
  • Karin M, Haslinger A, Holtgreve H, et al. (1984). "Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene.". Nature 308 (5959): 513-9. PMID 6323998. 
  • Schmidt CJ, Hamer DH, McBride OW (1984). "Chromosomal location of human metallothionein genes: implications for Menkes' disease.". Science 224 (4653): 1104-6. PMID 6719135. 
  • Karin M, Richards RI (1982). "Human metallothionein genes: molecular cloning and sequence analysis of the mRNA.". Nucleic Acids Res. 10 (10): 3165-73. PMID 6896577. 
  • Karin M, Richards RI (1982). "Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene.". Nature 299 (5886): 797-802. PMID 7133118. 
  • Lambert E, Kille P, Swaminathan R (1996). "Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes.". FEBS Lett. 389 (2): 210-2. PMID 8766831. 
  • Woo ES, Dellapiazza D, Wang AS, Lazo JS (1999). "Energy-dependent nuclear binding dictates metallothionein localization.". J. Cell. Physiol. 182 (1): 69-76. doi:10.1002/(SICI)1097-4652(200001)182:1<69::AID-JCP8>3.0.CO;2-9. PMID 10567918. 
  • Jiang LJ, Vasák M, Vallee BL, Maret W (2000). "Zinc transfer potentials of the alpha - and beta-clusters of metallothionein are affected by domain interactions in the whole molecule.". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2503-8. PMID 10716985. 
  • Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer.". Prostate 43 (2): 125-35. PMID 10754528. 
  • Ebert MP, Günther T, Hoffmann J, et al. (2000). "Expression of metallothionein II in intestinal metaplasia, dysplasia, and gastric cancer.". Cancer Res. 60 (7): 1995-2001. PMID 10766190. 
  • Toyama M, Yamashita M, Hirayama N, Murooka Y (2003). "Interactions of arsenic with human metallothionein-2.". J. Biochem. 132 (2): 217-21. PMID 12153718. 
  • Sun X, Kang YJ (2002). "Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity.". Exp. Biol. Med. (Maywood) 227 (8): 652-7. PMID 12192109. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191-7. doi:10.1038/nm822. PMID 12539042. 
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