Metallothionein 1A

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Metallothionein 1A
PDB rendering based on 1mhu.
Available structures: 1mhu, 1mrb, 2mhu
Identifiers
Symbol(s) MT1A; MGC32848; MT1; MT1S; MTC
External IDs OMIM: 156350 HomoloGene: 88733
Orthologs
Human Mouse
Entrez 4489 n/a
Ensembl ENSG00000205362 n/a
Uniprot P04731 n/a
Refseq NM_005946 (mRNA)
NP_005937 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 16: 55.23 - 55.23 Mb n/a
Pubmed search [1] n/a

Metallothionein 1A, also known as MT1A, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: MT1A metallothionein 1A.

[edit] Further reading

  • Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, et al. (2007). "Metallothionein: an overview.". World J. Gastroenterol. 13 (7): 993–6. PMID 17373731. 
  • Sutherland GR, Baker E, Callen DF, et al. (1990). "The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia.". Genomics 6 (1): 144–8. PMID 2303255. 
  • Grider A, Bailey LB, Cousins RJ (1990). "Erythrocyte metallothionein as an index of zinc status in humans.". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1259–62. PMID 2304897. 
  • Le Beau MM, Diaz MO, Karin M, Rowley JD (1985). "Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia.". Nature 313 (6004): 709–11. PMID 3856101. 
  • Hunziker PE, Kägi JH (1985). "Isolation and characterization of six human hepatic isometallothioneins.". Biochem. J. 231 (2): 375–82. PMID 4062903. 
  • Karin M, Eddy RL, Henry WM, et al. (1984). "Human metallothionein genes are clustered on chromosome 16.". Proc. Natl. Acad. Sci. U.S.A. 81 (17): 5494–8. PMID 6089206. 
  • Richards RI, Heguy A, Karin M (1984). "Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids.". Cell 37 (1): 263–72. PMID 6327055. 
  • Armitage IM, Otvos JD, Briggs RW, Boulanger Y (1983). "Structure elucidation of the metal-binding sites in metallothionein by 113Cd NMR.". Fed. Proc. 41 (13): 2974–80. PMID 7140998. 
  • Akintola DF, Sampson B, Fleck A (1995). "Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine.". J. Lab. Clin. Med. 126 (2): 119–27. PMID 7543551. 
  • Davis SR, McMahon RJ, Cousins RJ (1998). "Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression.". J. Nutr. 128 (5): 825–31. PMID 9566988. 
  • Simpkins C, Lloyd T, Li S, Balderman S (1998). "Metallothionein-induced increase in mitochondrial inner membrane permeability.". J. Surg. Res. 75 (1): 30–4. doi:10.1006/jsre.1997.5241. PMID 9614853. 
  • Lau JC, Cherian MG (1999). "Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice.". Biochem. Cell Biol. 76 (4): 615–23. PMID 10099782. 
  • Levadoux M, Mahon C, Beattie JH, et al. (2000). "Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton.". J. Biol. Chem. 274 (49): 34961–6. PMID 10574972. 
  • Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer.". Prostate 43 (2): 125–35. PMID 10754528. 
  • Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes.". Cell. Mol. Biol. (Noisy-le-grand) 46 (2): 419–33. PMID 10774930. 
  • Campagne MV, Thibodeaux H, van Bruggen N, et al. (2000). "Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion.". J. Neurosci. 20 (14): 5200–7. PMID 10884303. 
  • Rahman MT, De Ley M (2001). "Metallothionein isogene transcription in red blood cell precursors from human cord blood.". Eur. J. Biochem. 268 (3): 849–56. PMID 11168427. 
  • Levadoux-Martin M, Hesketh JE, Beattie JH, Wallace HM (2001). "Influence of metallothionein-1 localization on its function.". Biochem. J. 355 (Pt 2): 473–9. PMID 11284736. 
  • Richarz AN, Brätter P (2002). "Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins.". Analytical and bioanalytical chemistry 372 (3): 412–7. doi:10.1007/s00216-001-1187-5. PMID 11939525. 
  • Minami T, Kubo K, Ichida S (2003). "Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas by capillary zone electrophoresis using a polyacrylamide-coated capillary at neutral pH.". J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 779 (2): 211–9. PMID 12361735. 
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