METTL1

From Wikipedia, the free encyclopedia

Methyltransferase like 1

Identifiers

METTL1; C12orf1; TRM8; YDL201w

External IDs

OMIM: 604466 MGI: 1339986 HomoloGene: 3918

Gene ontology
Molecular Function:	• methyltransferase activity • tRNA (guanine-N7-)-methyltransferase activity • transferase activity
Cellular Component:	• cellular_component
Biological Process:	• tRNA modification • tRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005371 (mRNA)
NP_005362 (protein)

NM_010792 (mRNA)
NP_034922 (protein)

Location

Chr 12: 56.45 - 56.45 Mb

Chr 10: 126.44 - 126.45 Mb

Pubmed search

[1]

[2]

Methyltransferase like 1, also known as METTL1, is a human gene.^[1]

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphylation. Alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature.^[1]

[edit] References

^ ^a ^b Entrez Gene: METTL1 methyltransferase like 1.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Bahr A, Hankeln T, Fiedler T, et al. (1999). "Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation.". Genomics 57 (3): 424-8. doi:10.1006/geno.1999.5780. PMID 10329009.
Alexandrov A, Martzen MR, Phizicky EM (2002). "Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.". RNA 8 (10): 1253-66. PMID 12403464.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191-7. doi:10.1038/nm822. PMID 12539042.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Cartlidge RA, Knebel A, Peggie M, et al. (2005). "The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.". EMBO J. 24 (9): 1696-705. doi:10.1038/sj.emboj.7600648. PMID 15861136.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.