Mestranol
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Mestranol
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| Systematic (IUPAC) name | |
| (8S,9S,13S,14S,17S)-17-ethynyl-3-methoxy- 13-methyl-7,8,9,11,12,14,15,16-octahydro-6H- cyclopenta[a]phenanthren-17-ol |
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| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C21H26O2 |
| Mol. mass | 310.43 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
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| Legal status | |
| Routes | ? |
Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.
It is a biologically inactive prodrug of ethinylestradiol to which it is demethylated in the liver with a conversion efficiency of 70% (50 µg of mestranol is pharmacokinetically bioequivalent to 35 µg of ethinylestradiol).[1]
[edit] References
- ^ Faigle, Johann W.; Schenkel, Lotte (1998). "Pharmacokinetics of estrogens and progestogens", in in Fraser, Ian S. (ed.): Estrogens and Progestogens in Clinical Practice. London: Churchill Livingstone, pp. 273-294. ISBN 0-443-04706-5.
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