MEOX1

From Wikipedia, the free encyclopedia

Mesenchyme homeobox 1

Identifiers

External IDs

OMIM: 600147 MGI: 103220 HomoloGene: 3326

Gene ontology
Molecular Function:	• molecular_function • transcription factor activity • sequence-specific DNA binding
Cellular Component:	• cellular_component • nucleus
Biological Process:	• somite specification • regulation of transcription, DNA-dependent • multicellular organismal development • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001040002 (mRNA)
NP_001035091 (protein)

NM_010791 (mRNA)
NP_034921 (protein)

Location

Chr 17: 39.07 - 39.09 Mb

Chr 11: 101.69 - 101.71 Mb

Pubmed search

[1]

[2]

Mesenchyme homeobox 1, also known as MEOX1, is a human gene.^[1]

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: MEOX1 mesenchyme homeobox 1.

[edit] Further reading

Jones KA, Black DM, Brown MA, et al. (1995). "The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase.". Hum. Mol. Genet. 3 (11): 1927-34. PMID 7874108.
Futreal PA, Cochran C, Rosenthal J, et al. (1995). "Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture.". Hum. Mol. Genet. 3 (8): 1359-64. PMID 7987315.
Stelnicki EJ, Kömüves LG, Holmes D, et al. (1997). "The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin.". Differentiation 62 (1): 33-41. PMID 9373945.
Stamataki D, Kastrinaki M, Mankoo BS, et al. (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors.". FEBS Lett. 499 (3): 274-8. PMID 11423130.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Petropoulos H, Gianakopoulos PJ, Ridgeway AG, Skerjanc IS (2004). "Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells.". J. Biol. Chem. 279 (23): 23874-81. doi:10.1074/jbc.M312612200. PMID 15039437.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Gianakopoulos PJ, Skerjanc IS (2005). "Hedgehog signaling induces cardiomyogenesis in P19 cells.". J. Biol. Chem. 280 (22): 21022-8. doi:10.1074/jbc.M502977200. PMID 15793308.
Wissmüller S, Kosian T, Wolf M, et al. (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.". Nucleic Acids Res. 34 (6): 1735-44. doi:10.1093/nar/gkl105. PMID 16582099.