Membrane-bound transcription factor peptidase, site 2
From Wikipedia, the free encyclopedia
membrane-bound transcription factor peptidase, site 2
|
|
Identifiers | |
Symbol | MBTPS2 |
Alt. Symbols | S2P |
Entrez | 51360 |
HUGO | 15455 |
OMIM | 300294 |
RefSeq | NM_015884 |
UniProt | O43462 |
Other data | |
EC number | 3.4.24.85 |
Locus | Chr. X p22.1-p22.2 |
Membrane-bound transcription factor peptidase, site 2 also known as Site-2 Protease (S2P) is an enzyme (EC 3.4.24.85) encoded by the MBTPS2 gene which liberates the N-terminal fragment of sterol regulatory element binding protein (SREBP) transcription factors from membranes.[1][2]
[edit] See also
[edit] References
- ^ Brown MS, Goldstein JL (1999). "A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11041–8. doi: . PMID 10500120.
- ^ Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL (1997). "Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs". Mol. Cell 1 (1): 47–57. doi: . PMID 9659902.