Melanin-concentrating hormone receptor
From Wikipedia, the free encyclopedia
Identifiers | |
Symbol | MCHR1 |
Alt. Symbols | GPR24 |
Entrez | 2847 |
HUGO | 4479 |
OMIM | 601751 |
RefSeq | NM_005297 |
UniProt | Q99705 |
Other data | |
Locus | Chr. 22 q13.3 |
Identifiers | |
Symbol | MCHR2 |
Alt. Symbols | GPR145 |
Entrez | 84539 |
HUGO | 20867 |
OMIM | 606111 |
RefSeq | NM_032503 |
UniProt | Q969V1 |
Other data | |
Locus | Chr. 6 q16 |
Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.
- MCH-R1 is expressed in all mammals.
- MCH-R2 is only found in some primates and carnivores including dogs, ferrets and man.
Contents |
[edit] Clinical significance
Antagonists might be useful in the treatment of obesity[1][2] and anxiety and depression.[3] An agonist might have possible utility as a treatment for osteoporosis.[4]
Research is ongoing for antagonists affecting MCH receptors R1 and R2.[5][6]
[edit] References
- ^ Handlon AL, Zhou H (2006). "Melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity". J. Med. Chem. 49 (14): 4017–22. doi: . PMID 16821761.
- ^ Luthin DR (2007). "Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists". Life Sci. 81 (6): 423–40. doi: . PMID 17655875.
- ^ Shimazaki T, Yoshimizu T, Chaki S (2006). "Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders". CNS drugs 20 (10): 801–11. PMID 16999451.
- ^ Bohlooly-Y M, Mahlapuu M, Andersén H, Astrand A, Hjorth S, Svensson L, Törnell J, Snaith MR, Morgan DG, Ohlsson C (2004). "Osteoporosis in MCHR1-deficient mice". Biochem. Biophys. Res. Commun. 318 (4): 964–9. doi: . PMID 15147966.
- ^ Saito Y, Maruyama K (2006). "Identification of melanin-concentrating hormone receptor and its impact on drug discovery". J. Exp. Zoolog. Part A Comp. Exp. Biol. 305 (9): 761–8. doi: . PMID 16902961.
- ^ McBriar MD (2006). "Recent advances in the discovery of melanin-concentrating hormone receptor antagonists". Current opinion in drug discovery & development 9 (4): 496–508. PMID 16889232.
[edit] See also
[edit] External links
- IUPHAR GPCR Database - Melanin-concentrating hormone receptors
- MeSH melanin-concentrating+hormone+receptor
- MeSH MCHR1+protein,+human
- MeSH MCHR2+protein,+human