MELK

From Wikipedia, the free encyclopedia

Maternal embryonic leucine zipper kinase

Identifiers

MELK; HPK38; KIAA0175

External IDs

OMIM: 607025 MGI: 106924 HomoloGene: 32111

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Cellular Component:	• cytoplasm
Biological Process:	• protein amino acid phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014791 (mRNA)
NP_055606 (protein)

NM_010790 (mRNA)
NP_034920 (protein)

Location

Chr 9: 36.56 - 36.67 Mb

Chr 4: 44.32 - 44.39 Mb

Pubmed search

[1]

[2]

Maternal embryonic leucine zipper kinase, also known as MELK, is a human gene.^[1]

[edit] References

^ Entrez Gene: MELK maternal embryonic leucine zipper kinase.

[edit] Further reading

Lin ML, Park JH, Nishidate T, et al. (2007). "Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family.". Breast Cancer Res. 9 (1): R17. doi:10.1186/bcr1650. PMID 17280616.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Beullens M, Vancauwenbergh S, Morrice N, et al. (2006). "Substrate specificity and activity regulation of protein kinase MELK.". J. Biol. Chem. 280 (48): 40003–11. doi:10.1074/jbc.M507274200. PMID 16216881.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Vulsteke V, Beullens M, Boudrez A, et al. (2004). "Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1.". J. Biol. Chem. 279 (10): 8642–7. doi:10.1074/jbc.M311466200. PMID 14699119.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Davezac N, Baldin V, Blot J, et al. (2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation.". Oncogene 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. PMID 12400006.
Seong HA, Gil M, Kim KT, et al. (2002). "Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38).". Biochem. J. 361 (Pt 3): 597–604. PMID 11802789.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Gil M, Yang Y, Lee Y, et al. (1997). "Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells.". Gene 195 (2): 295–301. PMID 9305775.
Heyer BS, Warsowe J, Solter D, et al. (1997). "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo.". Mol. Reprod. Dev. 47 (2): 148–56. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115.
Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. PMID 8724849.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.