MEF2C

From Wikipedia, the free encyclopedia


MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)
PDB rendering based on 1c7u.
Available structures: 1c7u, 1egw
Identifiers
Symbol(s) MEF2C;
External IDs OMIM: 600662 MGI: 99458 HomoloGene: 31087
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4208 17260
Ensembl ENSG00000081189 ENSMUSG00000005583
Uniprot Q06413 n/a
Refseq NM_002397 (mRNA)
NP_002388 (protein)		 NM_025282 (mRNA)
NP_079558 (protein)
Location Chr 5: 88.05 - 88.21 Mb Chr 13: 83.98 - 84.14 Mb
Pubmed search [1] [2]

MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C), also known as MEF2C, is a transcription factor in the Mef2 family.[1][2] The Mef2c gene is necessary for proper embryonic development: mice without a functional copy of the Mef2c gene die before birth and have abnormalities in the heart and vascular system.[3]


Contents

[edit] See also

[edit] References

  1. ^ Molkentin JD, Black BL, Martin JF, Olson EN (1996). "Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.". Mol Cell Biol. 16 (6): 2627–36. PMID 8649370. 
  2. ^ Entrez Gene: MEF2C myocyte enhancer factor 2C.
  3. ^ Bi W, Drake CJ, Schwarz JJ (1999). "The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF". Developmental Biology 211 (2): 255–67. doi:10.1006/dbio.1999.9307. PMID 10395786. 

[edit] Further reading

  • Leifer D, Krainc D, Yu YT, et al. (1993). "MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.". Proc. Natl. Acad. Sci. U.S.A. 90 (4): 1546–50. PMID 7679508. 
  • McDermott JC, Cardoso MC, Yu YT, et al. (1993). "hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.". Mol. Cell. Biol. 13 (4): 2564–77. PMID 8455629. 
  • Hobson GM, Krahe R, Garcia E, et al. (1996). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.". Genomics 29 (3): 704–11. doi:10.1006/geno.1995.9007. PMID 8575763. 
  • Krainc D, Haas M, Ward DC, et al. (1996). "Assignment of human myocyte-specific enhancer binding factor 2C (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is evolutionarily conserved.". Genomics 29 (3): 809–11. doi:10.1006/geno.1995.9927. PMID 8575784. 
  • Molkentin JD, Li L, Olson EN (1996). "Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity.". J. Biol. Chem. 271 (29): 17199–204. PMID 8663403. 
  • Black BL, Ligon KL, Zhang Y, Olson EN (1996). "Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family.". J. Biol. Chem. 271 (43): 26659–63. PMID 8900141. 
  • Gradwohl G, Fode C, Guillemot F (1997). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors.". Dev. Biol. 180 (1): 227–41. doi:10.1006/dbio.1996.0297. PMID 8948587. 
  • Sartorelli V, Huang J, Hamamori Y, Kedes L (1997). "Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C.". Mol. Cell. Biol. 17 (2): 1010–26. PMID 9001254. 
  • Han J, Jiang Y, Li Z, et al. (1997). "Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.". Nature 386 (6622): 296–9. doi:10.1038/386296a0. PMID 9069290. 
  • Kato Y, Kravchenko VV, Tapping RI, et al. (1998). "BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.". EMBO J. 16 (23): 7054–66. doi:10.1093/emboj/16.23.7054. PMID 9384584. 
  • Krainc D, Bai G, Okamoto S, et al. (1998). "Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1.". J. Biol. Chem. 273 (40): 26218–24. PMID 9748305. 
  • Yang CC, Ornatsky OI, McDermott JC, et al. (1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1.". Nucleic Acids Res. 26 (20): 4771–7. PMID 9753748. 
  • Swanson BJ, Jäck HM, Lyons GE (1998). "Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes.". Mol. Immunol. 35 (8): 445–58. PMID 9798649. 
  • Zhao M, New L, Kravchenko VV, et al. (1999). "Regulation of the MEF2 family of transcription factors by p38.". Mol. Cell. Biol. 19 (1): 21–30. PMID 9858528. 
  • Wilson-Rawls J, Molkentin JD, Black BL, Olson EN (1999). "Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C.". Mol. Cell. Biol. 19 (4): 2853–62. PMID 10082551. 
  • Yang SH, Galanis A, Sharrocks AD (1999). "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.". Mol. Cell. Biol. 19 (6): 4028–38. PMID 10330143. 
  • Wang AH, Bertos NR, Vezmar M, et al. (1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.". Mol. Cell. Biol. 19 (11): 7816–27. PMID 10523670. 
  • Lu J, McKinsey TA, Nicol RL, Olson EN (2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4070–5. doi:10.1073/pnas.080064097. PMID 10737771. 
  • Morin S, Charron F, Robitaille L, Nemer M (2000). "GATA-dependent recruitment of MEF2 proteins to target promoters.". EMBO J. 19 (9): 2046–55. doi:10.1093/emboj/19.9.2046. PMID 10790371. 
  • Wu Z, Woodring PJ, Bhakta KS, et al. (2000). "p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps.". Mol. Cell. Biol. 20 (11): 3951–64. PMID 10805738. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD