MED8

From Wikipedia, the free encyclopedia

Mediator of RNA polymerase II transcription, subunit 8 homolog (S. cerevisiae)

Identifiers

MED8; ARC32; MGC17544; MGC19641

External IDs

OMIM: 607956 MGI: 1915269 HomoloGene: 10560

Gene ontology
Molecular Function:	• receptor activity
Cellular Component:	• mediator complex • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001001651 (mRNA)
NP_001001651 (protein)

NM_020000 (mRNA)
NP_064384 (protein)

Location

Chr 1: 43.62 - 43.63 Mb

Chr 4: 117.91 - 117.91 Mb

Pubmed search

[1]

[2]

Mediator of RNA polymerase II transcription, subunit 8 homolog (S. cerevisiae), also known as MED8, is a human gene.^[1]

This gene encodes a protein that is one of more than 20 subunits of the mediator complex, first identified in S. cerevisiae, that is required for activation of transcription. The product of this gene also interacts with elongins B and C, and CUL2 and RBX1, to reconstitute a ubiquitin ligase. Five alternative transcripts encoding four isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: MED8 mediator of RNA polymerase II transcription, subunit 8 homolog (S. cerevisiae).

[edit] Further reading

Jiang YW, Veschambre P, Erdjument-Bromage H, et al. (1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways.". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8538-43. PMID 9671713.
Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation.". Nature 398 (6730): 828-32. doi:10.1038/19789. PMID 10235267.
Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089-94. doi:10.1073/pnas.241522398. PMID 11752456.
Brower CS, Sato S, Tomomori-Sato C, et al. (2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10353-8. doi:10.1073/pnas.162424199. PMID 12149480.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.". J. Biol. Chem. 278 (17): 15123-7. doi:10.1074/jbc.C300054200. PMID 12584197.
Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671-4. doi:10.1074/jbc.C300444200. PMID 14576168.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846-51. doi:10.1074/jbc.M312523200. PMID 14638676.
Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685-91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Léonard VH, Kohl A, Hart TJ, Elliott RM (2006). "Interaction of Bunyamwera Orthobunyavirus NSs protein with mediator protein MED8: a mechanism for inhibiting the interferon response.". J. Virol. 80 (19): 9667-75. doi:10.1128/JVI.00822-06. PMID 16973571.