MED7
From Wikipedia, the free encyclopedia
Cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa
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Identifiers | ||||||||||||||
Symbol(s) | CRSP9; CRSP33; MED7; MGC12284 | |||||||||||||
External IDs | OMIM: 605045 MGI: 2159682 HomoloGene: 3153 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 9443 | 171285 | ||||||||||||
Ensembl | ENSG00000155868 | ENSMUSG00000020399 | ||||||||||||
Uniprot | O43513 | Q3KP82 | ||||||||||||
Refseq | NM_004270 (mRNA) NP_004261 (protein) |
NM_134250 (mRNA) NP_599011 (protein) |
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Location | Chr 5: 156.49 - 156.5 Mb | Chr 11: 46.3 - 46.32 Mb | ||||||||||||
Pubmed search | [1] | [2] |
Cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa, also known as CRSP9, is a human gene.[1]
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.[1]
[edit] References
[edit] Further reading
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi: . PMID 17353931.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi: . PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi: . PMID 15489334.
- Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685–91. doi: . PMID 15175163.
- Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846–51. doi: . PMID 14638676.
- Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671–4. doi: . PMID 14576168.
- Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.". J. Biol. Chem. 278 (17): 15123–7. doi: . PMID 12584197.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: . PMID 12477932.
- Ryu S, Tjian R (1999). "Purification of transcription cofactor complex CRSP.". Proc. Natl. Acad. Sci. U.S.A. 96 (13): 7137–42. PMID 10377381.
- Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation.". Nature 398 (6730): 828–32. doi: . PMID 10235267.
- Ryu S, Zhou S, Ladurner AG, Tjian R (1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.". Nature 397 (6718): 446–50. doi: . PMID 9989412.
- Jiang YW, Veschambre P, Erdjument-Bromage H, et al. (1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways.". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8538–43. PMID 9671713.
- Myers LC, Gustafsson CM, Bushnell DA, et al. (1998). "The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain.". Genes Dev. 12 (1): 45–54. PMID 9420330.