MED30

From Wikipedia, the free encyclopedia

Thyroid hormone receptor associated protein 6

Identifiers

THRAP6; MED30; MGC9890; TRAP25

External IDs

OMIM: 610237 MGI: 1917040 HomoloGene: 12329

Gene ontology
Molecular Function:	• transcription cofactor activity • receptor activity • RNA polymerase II transcription mediator activity • transcription activator activity • ligand-dependent nuclear receptor transcription coactivator activity • identical protein binding • vitamin D receptor binding • thyroid hormone receptor binding
Cellular Component:	• mediator complex • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • androgen receptor signaling pathway

Orthologs

Human

Mouse

Refseq

NM_080651 (mRNA)
NP_542382 (protein)

NM_027212 (mRNA)
NP_081488 (protein)

Location

Chr 8: 118.6 - 118.62 Mb

Chr 15: 52.54 - 52.56 Mb

Pubmed search

[1]

[2]

Thyroid hormone receptor associated protein 6, also known as THRAP6, is a human gene.^[1]

[edit] References

^ Entrez Gene: THRAP6 thyroid hormone receptor associated protein 6.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.". J. Biol. Chem. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.
Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome.". Nucleic Acids Res. 30 (14): 3163–70. PMID 12136098.
Baek HJ, Malik S, Qin J, Roeder RG (2002). "Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s.". Mol. Cell. Biol. 22 (8): 2842–52. PMID 11909976.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653.
Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation.". Nature 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.". Nature 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.
Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.". Mol. Cell 3 (3): 361–70. PMID 10198638.