MED26

From Wikipedia, the free encyclopedia

Cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa

Identifiers

CRSP7; CRSP70; MED26

External IDs

OMIM: 605043 MGI: 1917875 HomoloGene: 68417

Gene ontology
Molecular Function:	• transcription coactivator activity • receptor activity • protein binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter

Orthologs

Human

Mouse

n/a

Refseq

NM_004831 (mRNA)
NP_004822 (protein)

NM_027485 (mRNA)
NP_081761 (protein)

Location

Chr 19: 16.55 - 16.6 Mb

Chr 8: 75.42 - 75.48 Mb

Pubmed search

[1]

[2]

Cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa, also known as CRSP7, is a human gene.^[1]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.^[1]

[edit] References

^ ^a ^b Entrez Gene: CRSP7 cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa.

[edit] Further reading

Ryu S, Zhou S, Ladurner AG, Tjian R (1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.". Nature 397 (6718): 446-50. doi:10.1038/17141. PMID 9989412.
Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation.". Nature 398 (6730): 828-32. doi:10.1038/19789. PMID 10235267.
Booth V, Koth CM, Edwards AM, Arrowsmith CH (2000). "Structure of a conserved domain common to the transcription factors TFIIS, elongin A, and CRSP70.". J. Biol. Chem. 275 (40): 31266-8. doi:10.1074/jbc.M002595200. PMID 10811649.
Näär AM, Taatjes DJ, Zhai W, et al. (2002). "Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation.". Genes Dev. 16 (11): 1339-44. doi:10.1101/gad.987602. PMID 12050112.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671-4. doi:10.1074/jbc.C300444200. PMID 14576168.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846-51. doi:10.1074/jbc.M312523200. PMID 14638676.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Mo X, Kowenz-Leutz E, Xu H, Leutz A (2004). "Ras induces mediator complex exchange on C/EBP beta.". Mol. Cell 13 (2): 241-50. PMID 14759369.
Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685-91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Zhang X, Krutchinsky A, Fukuda A, et al. (2005). "MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.". Mol. Cell 19 (1): 89-100. doi:10.1016/j.molcel.2005.05.015. PMID 15989967.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.