MED24

From Wikipedia, the free encyclopedia

Thyroid hormone receptor associated protein 4

Identifiers

THRAP4; MED24; ARC100; DRIP100; KIAA0130; MGC8748; TRAP100

External IDs

OMIM: 607000 MGI: 1344385 HomoloGene: 40795

Gene ontology
Molecular Function:	• nucleotide binding • transcription cofactor activity • receptor activity • ATP binding • zinc ion binding • RNA polymerase II transcription mediator activity • transcription activator activity • ligand-dependent nuclear receptor transcription coactivator activity • vitamin D receptor binding • metal ion binding • thyroid hormone receptor binding
Cellular Component:	• mediator complex • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • androgen receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001079518 (mRNA)
NP_001072986 (protein)

NM_011869 (mRNA)
NP_035999 (protein)

Location

Chr 17: 35.43 - 35.46 Mb

Chr 11: 98.35 - 98.55 Mb

Pubmed search

[1]

[2]

Thyroid hormone receptor associated protein 4, also known as THRAP4, is a human gene.^[1]

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: THRAP4 thyroid hormone receptor associated protein 4.

[edit] Further reading

Gustafsson CM, Samuelsson T (2001). "Mediator--a universal complex in transcriptional regulation.". Mol. Microbiol. 41 (1): 1-8. PMID 11454195.
Malik S, Roeder RG (2005). "Dynamic regulation of pol II transcription by the mammalian Mediator complex.". Trends Biochem. Sci. 30 (5): 256-63. doi:10.1016/j.tibs.2005.03.009. PMID 15896744.
Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167-74, 199-210. PMID 8590280.
Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329-33. PMID 8710870.
Rachez C, Suldan Z, Ward J, et al. (1998). "A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system.". Genes Dev. 12 (12): 1787-800. PMID 9637681.
Yuan CX, Ito M, Fondell JD, et al. (1998). "The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 7939-44. PMID 9653119.
Gu W, Malik S, Ito M, et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.". Mol. Cell 3 (1): 97-108. PMID 10024883.
Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.". Mol. Cell 3 (3): 361-70. PMID 10198638.
Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.". Nature 398 (6730): 824-8. doi:10.1038/19783. PMID 10235266.
Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation.". Nature 398 (6730): 828-32. doi:10.1038/19789. PMID 10235267.
Ryu S, Tjian R (1999). "Purification of transcription cofactor complex CRSP.". Proc. Natl. Acad. Sci. U.S.A. 96 (13): 7137-42. PMID 10377381.
Zhang J, Fondell JD (1999). "Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors.". Mol. Endocrinol. 13 (7): 1130-40. PMID 10406464.
Taatjes DJ, Näär AM, Andel F, et al. (2002). "Structure, function, and activator-induced conformations of the CRSP coactivator.". Science 295 (5557): 1058-62. doi:10.1126/science.1065249. PMID 11834832.
Surapureddi S, Yu S, Bu H, et al. (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836-41. doi:10.1073/pnas.182426699. PMID 12189208.
Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.". J. Biol. Chem. 277 (45): 42852-8. doi:10.1074/jbc.M206061200. PMID 12218053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671-4. doi:10.1074/jbc.C300444200. PMID 14576168.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846-51. doi:10.1074/jbc.M312523200. PMID 14638676.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.