MED21

From Wikipedia, the free encyclopedia

SRB7 suppressor of RNA polymerase B homolog (yeast)

Identifiers

SURB7; MED21; SRB7

External IDs

OMIM: 603800 MGI: 1347064 HomoloGene: 3148

Gene ontology
Molecular Function:	• RNA polymerase II transcription factor activity • transcription coactivator activity • DNA-directed RNA polymerase activity • protein binding
Cellular Component:	• mediator complex • nucleus • DNA-directed RNA polymerase II, core complex
Biological Process:	• transcription • positive regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004264 (mRNA)
NP_004255 (protein)

NM_025315 (mRNA)
NP_079591 (protein)

Location

Chr 12: 27.07 - 27.07 Mb

Chr 6: 146.6 - 146.61 Mb

Pubmed search

[1]

[2]

SRB7 suppressor of RNA polymerase B homolog (yeast), also known as SURB7, is a human gene.^[1]

[edit] References

^ Entrez Gene: SURB7 SRB7 suppressor of RNA polymerase B homolog (yeast).

[edit] Further reading

Zheng XM, Black D, Chambon P, Egly JM (1990). "Sequencing and expression of complementary DNA for the general transcription factor BTF3.". Nature 344 (6266): 556–9. doi:10.1038/344556a0. PMID 2320128.
Chao DM, Gadbois EL, Murray PJ, et al. (1996). "A mammalian SRB protein associated with an RNA polymerase II holoenzyme.". Nature 380 (6569): 82–5. doi:10.1038/380082a0. PMID 8598913.
Maldonado E, Shiekhattar R, Sheldon M, et al. (1996). "A human RNA polymerase II complex associated with SRB and DNA-repair proteins.". Nature 381 (6577): 86–9. doi:10.1038/381086a0. PMID 8609996.
Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817–23. PMID 9121429.
Scully R, Anderson SF, Chao DM, et al. (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme.". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. PMID 9159119.
Pan G, Aso T, Greenblatt J (1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators.". J. Biol. Chem. 272 (39): 24563–71. PMID 9305922.
Cho H, Orphanides G, Sun X, et al. (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure.". Mol. Cell. Biol. 18 (9): 5355–63. PMID 9710619.
Sun X, Zhang Y, Cho H, et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription.". Mol. Cell 2 (2): 213–22. PMID 9734358.
Garriga J, Peng J, Parreño M, et al. (1999). "Upregulation of cyclin T1/CDK9 complexes during T cell activation.". Oncogene 17 (24): 3093–102. doi:10.1038/sj.onc.1202548. PMID 9872325.
Gu W, Malik S, Ito M, et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.". Mol. Cell 3 (1): 97–108. PMID 10024883.
Ramanathan Y, Rajpara SM, Reza SM, et al. (2001). "Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences.". J. Biol. Chem. 276 (14): 10913–20. doi:10.1074/jbc.M010975200. PMID 11278802.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653.
Ge K, Guermah M, Yuan CX, et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.". Nature 417 (6888): 563–7. doi:10.1038/417563a. PMID 12037571.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Wallberg AE, Yamamura S, Malik S, et al. (2004). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.". Mol. Cell 12 (5): 1137–49. PMID 14636573.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Nevado J, Tenbaum SP, Aranda A (2005). "hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor.". Mol. Cell. Endocrinol. 222 (1-2): 41–51. doi:10.1016/j.mce.2004.05.003. PMID 15249124.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.