MED16

From Wikipedia, the free encyclopedia

Thyroid hormone receptor associated protein 5

Identifiers

THRAP5; DRIP92; MED16; TRAP95

External IDs

OMIM: 604062 MGI: 2158394 HomoloGene: 64602

Gene ontology
Molecular Function:	• transcription coactivator activity • receptor activity • thyroid hormone receptor coactivator activity • vitamin D receptor binding • thyroid hormone receptor binding
Cellular Component:	• mediator complex • nucleus
Biological Process:	• transcription • regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • androgen receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001130102 (mRNA)
XP_001130102 (protein)

NM_198107 (mRNA)
NP_932775 (protein)

Location

Chr 19: 0.82 - 0.84 Mb

Chr 10: 79.3 - 79.31 Mb

Pubmed search

[1]

[2]

Thyroid hormone receptor associated protein 5, also known as THRAP5, is a human gene.^[1]

[edit] References

^ Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5.

[edit] Further reading

Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. PMID 8710870.
Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.". Mol. Cell 3 (3): 361–70. PMID 10198638.
Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.". Nature 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMID 11337467.
Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.". J. Biol. Chem. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Wallberg AE, Yamamura S, Malik S, et al. (2004). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.". Mol. Cell 12 (5): 1137–49. PMID 14636573.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.