MED15

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PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
PDB rendering based on 2gut.
Available structures: 2gut
Identifiers
Symbol(s) PCQAP; TIG1; ARC105; CAG7A; CTG7A; DKFZp686A2214; DKFZp762B1216; FLJ42282; FLJ42935; MED15; TIG-1; TNRC7
External IDs OMIM: 607372 MGI: 2137379 HomoloGene: 32283
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51586 94112
Ensembl ENSG00000099917 ENSMUSG00000012114
Uniprot Q96RN5 A0JLM5
Refseq NM_001003891 (mRNA)
NP_001003891 (protein)		 NM_001040683 (mRNA)
NP_001035773 (protein)
Location Chr 22: 19.19 - 19.27 Mb Chr 16: 17.56 - 17.64 Mb
Pubmed search [1] [2]

PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein, also known as PCQAP, is a human gene.[1]

The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: PCQAP PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein.

[edit] Further reading

  • Margolis RL, Abraham MR, Gatchell SB, et al. (1997). "cDNAs with long CAG trinucleotide repeats from human brain.". Hum. Genet. 100 (1): 114–22. PMID 9225980. 
  • Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation.". Nature 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267. 
  • Abraham S, Solomon WB (2000). "A novel glutamine-rich putative transcriptional adaptor protein (TIG-1), preferentially expressed in placental and bone-marrow tissues.". Gene 255 (2): 389–400. PMID 11024300. 
  • Berti L, Mittler G, Przemeck GK, et al. (2001). "Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit.". Genomics 74 (3): 320–32. doi:10.1006/geno.2001.6566. PMID 11414760. 
  • Kato Y, Habas R, Katsuyama Y, et al. (2002). "A component of the ARC/Mediator complex required for TGF beta/Nodal signalling.". Nature 418 (6898): 641–6. doi:10.1038/nature00969. PMID 12167862. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • De Luca A, Conti E, Grifone N, et al. (2003). "Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 116 (1): 32–5. doi:10.1002/ajmg.b.10008. PMID 12497610. 
  • Zhang J, Liu L, Pfeifer GP (2004). "Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene.". Oncogene 23 (12): 2241–9. doi:10.1038/sj.onc.1207328. PMID 14691453. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Yang F, DeBeaumont R, Zhou S, Näär AM (2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2339–44. PMID 14983011. 
  • Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163. 
  • Sandhu HK, Hollenbeck N, Wassink TH, Philibert RA (2005). "An association study of PCQAP polymorphisms and schizophrenia.". Psychiatr. Genet. 14 (3): 169–72. PMID 15318033. 
  • Kwong J, Lo KW, Chow LS, et al. (2005). "Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma.". Int. J. Cancer 113 (3): 386–92. doi:10.1002/ijc.20593. PMID 15455391. 
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Yang F, Vought BW, Satterlee JS, et al. (2006). "An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.". Nature 442 (7103): 700–4. doi:10.1038/nature04942. PMID 16799563. 
  • Ishikawa H, Tachikawa H, Miura Y, Takahashi N (2006). "TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system.". FEBS Lett. 580 (20): 4784–92. doi:10.1016/j.febslet.2006.07.066. PMID 16904669. 
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