Meclizine

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Meclizine
Systematic (IUPAC) name
1-[(4-chlorophenyl)- phenyl-methyl]-4- [(3-methylphenyl)methyl]piperazine
Identifiers
CAS number	569-65-3
ATC code	A04AB04 R06AE05
PubChem	4034
DrugBank	APRD00354
Chemical data
Formula	C25H27ClN2
Mol. mass	390.948 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	6 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	B(US)
Legal status
Routes	Oral

Meclizine (proposed INN is meclozine) is an antihistamine considered to be an antiemetic. It is sold over the counter under the brand names of Bonine, Antivert and Postafen and is most commonly used to inhibit nausea and vomiting. An alternative to dimenhydrinate (Dramamine), meclizine is considered to be equally effective, but with reduced side effects.

Contents 1 Uses 1.1 Motion sickness 1.2 Vertigo 2 Risks of use 2.1 Drowsiness 2.2 Anticholinergics 3 External links

[edit] Uses

[edit] Motion sickness

Meclizine is effective in inhibiting the symptoms of motion sickness, such as nausea, vomiting, and dizziness.

[edit] Vertigo

Meclizine may be effective in relieving vertigo experienced as a result of inner ear infections or other conditions.

[edit] Risks of use

[edit] Drowsiness

Drowsiness may result as a side effect of taking meclizine. While the effects are less than dimenhydrinate, users are advised not to operate heavy machinery while under the influence. The consumption of alcohol while under the influence of meclizine may result in additional drowsiness.

[edit] Anticholinergics

Due to its possible anticholinergic action, meclizine should be used carefully with patients who suffer from asthma, glaucoma, or an enlarged prostate gland.

[edit] External links

• University of Berlin's Institute of Biochemistry
• Numark Pharmacies Information Page on Meclizine
• Rxlist Medical Dictionary

v • d • e Antihistamines (primarily R06) Aminoalkyl ethers Bromazine/Bromodiphenhydramine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine Substituted alkylamines Brompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine Substituted ethylenediamines Chloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine) Phenothiazine derivatives Alimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine Piperazine derivatives Buclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide Others for systemic use Antazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine) For topical use Bamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine Antiallergic agents excluding corticosteroids Antazoline • Azelastine Other antiallergics Emedastine • Epinastine • Ketotifen • Montelukast • Olopatadine