MDFI

From Wikipedia, the free encyclopedia

MyoD family inhibitor

Identifiers

MDFI; I-MF

External IDs

Gene ontology
Molecular Function:	• receptor activity • protein binding
Cellular Component:	• cytoplasm
Biological Process:	• embryonic development • cell differentiation • cytoplasmic sequestering of transcription factor

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_005586 (mRNA)
NP_005577 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 6: 41.71 - 41.73 Mb

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Pubmed search

[1]

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MyoD family inhibitor, also known as MDFI, is a human gene.^[1]

This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interfers with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.^[1]

[edit] References

^ ^a ^b Entrez Gene: MDFI MyoD family inhibitor.

[edit] Further reading

Chen CM, Kraut N, Groudine M, Weintraub H (1996). "I-mf, a novel myogenic repressor, interacts with members of the MyoD family.". Cell 86 (5): 731–41. PMID 8797820.
Kraut N (1997). "The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse chromosome 17.". Mamm. Genome 8 (8): 618–9. PMID 9250874.
Kraut N, Snider L, Chen CM, et al. (1999). "Requirement of the mouse I-mfa gene for placental development and skeletal patterning.". EMBO J. 17 (21): 6276–88. doi:10.1093/emboj/17.21.6276. PMID 9799236.
Snider L, Thirlwell H, Miller JR, et al. (2001). "Inhibition of Tcf3 binding by I-mfa domain proteins.". Mol. Cell. Biol. 21 (5): 1866–73. doi:10.1128/MCB.21.5.1866-1873.2001. PMID 11238923.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ma R, Rundle D, Jacks J, et al. (2004). "Inhibitor of myogenic family, a novel suppressor of store-operated currents through an interaction with TRPC1.". J. Biol. Chem. 278 (52): 52763–72. doi:10.1074/jbc.M309610200. PMID 14530267.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Mizugishi K, Hatayama M, Tohmonda T, et al. (2004). "Myogenic repressor I-mfa interferes with the function of Zic family proteins.". Biochem. Biophys. Res. Commun. 320 (1): 233–40. doi:10.1016/j.bbrc.2004.05.158. PMID 15207726.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.