MCL1

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Myeloid cell leukemia sequence 1 (BCL2-related)
PDB rendering based on 2nl9.
Available structures: 2nl9, 2nla
Identifiers
Symbol(s)	MCL1; EAT; MCL1L; MCL1S; MGC104264; MGC1839; TM
External IDs	OMIM: 159552 MGI: 101769 HomoloGene: 7413
Gene ontology Molecular Function: • protein binding • protein channel activity • protein heterodimerization activity Cellular Component: • nucleus • cytoplasm • mitochondrion • mitochondrial outer membrane • membrane • integral to membrane Biological Process: • cell fate determination • anti-apoptosis • multicellular organismal development • apoptotic program • cell homeostasis • cell differentiation • regulation of apoptosis
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	4170	17210
Ensembl	ENSG00000143384	ENSMUSG00000038612
Uniprot	Q07820	P97287
Refseq	NM_021960 (mRNA) NP_068779 (protein)	XM_976767 (mRNA) XP_981861 (protein)
Location	Chr 1: 148.81 - 148.82 Mb	Chr 3: 95.74 - 95.75 Mb
Pubmed search	[1]	[2]

Myeloid cell leukemia sequence 1 (BCL2-related), also known as MCL1, is a human gene.

The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.^[1]

[edit] See also

• Bcl-2

[edit] References

[edit] Further reading