MCF2

From Wikipedia, the free encyclopedia

MCF.2 cell line derived transforming sequence

Identifiers

External IDs

OMIM: 311030 MGI: 96932 HomoloGene: 3917

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity
Cellular Component:	• intracellular • membrane fraction • cytosol • cytoskeleton
Biological Process:	• intracellular signaling cascade • regulation of Rho protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_005369 (mRNA)
NP_005360 (protein)

NM_133197 (mRNA)
NP_573460 (protein)

Location

Chr X: 138.49 - 138.6 Mb

Chr X: 56.4 - 56.53 Mb

Pubmed search

[1]

[2]

MCF.2 cell line derived transforming sequence, also known as MCF2, is a human gene.^[1]

MCF2 is a member of a large family of GDP-GTP exchange factors that modulate the activity of small GTPases of the Rho family. Five-prime recombinations result in the loss of N-terminal codons, producing MCF2 variants with oncogenic potential.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence.

[edit] Further reading

Galland F, Stefanova M, Lafage M, Birnbaum D (1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23.". Cytogenet. Cell Genet. 60 (2): 114-6. PMID 1611909.
Ron D, Zannini M, Lewis M, et al. (1991). "A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr.". New Biol. 3 (4): 372-9. PMID 2065022.
Noguchi T, Galland F, Batoz M, et al. (1994). "Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences.". Oncogene 3 (6): 709-15. PMID 2577874.
Tronick SR, McBride OW, Popescu NC, Eva A (1990). "Chromosomal localization of DBL oncogene sequences.". Genomics 5 (3): 546-53. PMID 2613238.
Ron D, Tronick SR, Aaronson SA, Eva A (1989). "Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.". EMBO J. 7 (8): 2465-73. PMID 3056717.
Eva A, Vecchio G, Rao CD, et al. (1988). "The predicted DBL oncogene product defines a distinct class of transforming proteins.". Proc. Natl. Acad. Sci. U.S.A. 85 (7): 2061-5. PMID 3281159.
Srivastava SK, Wheelock RH, Aaronson SA, Eva A (1987). "Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene.". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 8868-72. PMID 3491366.
Hart MJ, Eva A, Zangrilli D, et al. (1994). "Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.". J. Biol. Chem. 269 (1): 62-5. PMID 8276860.
Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits.". FEBS Lett. 459 (2): 186-90. PMID 10518015.
Kato J, Kaziro Y, Satoh T (2000). "Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation.". Biochem. Biophys. Res. Commun. 268 (1): 141-7. doi:10.1006/bbrc.2000.2106. PMID 10652228.
Zhu K, Debreceni B, Li R, Zheng Y (2000). "Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation.". J. Biol. Chem. 275 (34): 25993-6001. doi:10.1074/jbc.M003780200. PMID 10854437.
Palmieri G, de Franciscis V, Casamassimi A, et al. (2000). "Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site.". Gene 253 (1): 107-15. PMID 10925207.
Jin S, Exton JH (2000). "Activation of RhoA by association of Galpha(13) with Dbl.". Biochem. Biophys. Res. Commun. 277 (3): 718-21. doi:10.1006/bbrc.2000.3744. PMID 11062019.
Zhu K, Debreceni B, Bi F, Zheng Y (2001). "Oligomerization of DH domain is essential for Dbl-induced transformation.". Mol. Cell. Biol. 21 (2): 425-37. doi:10.1128/MCB.21.2.425-437.2001. PMID 11134331.
Vanni C, Mancini P, Gao Y, et al. (2002). "Regulation of proto-Dbl by intracellular membrane targeting and protein stability.". J. Biol. Chem. 277 (22): 19745-53. doi:10.1074/jbc.M111025200. PMID 11907027.
Wennerberg K, Ellerbroek SM, Liu RY, et al. (2003). "RhoG signals in parallel with Rac1 and Cdc42.". J. Biol. Chem. 277 (49): 47810-7. doi:10.1074/jbc.M203816200. PMID 12376551.
Komai K, Okayama R, Kitagawa M, et al. (2003). "Alternative splicing variants of the human DBL (MCF-2) proto-oncogene.". Biochem. Biophys. Res. Commun. 299 (3): 455-8. PMID 12445822.
Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S (2003). "Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene.". Biochem. Biophys. Res. Commun. 309 (4): 906-9. PMID 13679059.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.