MCAT (gene)

From Wikipedia, the free encyclopedia

Malonyl CoA:ACP acyltransferase (mitochondrial)

PDB rendering based on 2c2n.

Available structures: 2c2n

Identifiers

Symbol(s)

MCAT; MT; MCT; FASN2C; MGC47838; fabD

External IDs

MGI: 2388651 HomoloGene: 15511

Gene ontology
Molecular Function:	• [acyl-carrier-protein S-malonyltransferase activity] • transferase activity
Cellular Component:	• mitochondrion
Biological Process:	• fatty acid biosynthetic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_014507 (mRNA)
NP_055322 (protein)

XM_912803 (mRNA)
XP_917896 (protein)

Location

Chr 22: 41.86 - 41.87 Mb

n/a

Pubmed search

[1]

[2]

Malonyl CoA:ACP acyltransferase (mitochondrial), also known as MCAT, is a human gene.^[1]

The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: MCAT malonyl CoA:ACP acyltransferase (mitochondrial).

[edit] Further reading

Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
Kuhl JE, Ruderman NB, Musi N, et al. (2006). "Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle.". Am. J. Physiol. Endocrinol. Metab. 290 (6): E1296–303. doi:10.1152/ajpendo.00341.2005. PMID 16434556.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang L, Joshi AK, Smith S (2003). "Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein.". J. Biol. Chem. 278 (41): 40067–74. doi:10.1074/jbc.M306121200. PMID 12882974.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22.". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMID 12529303.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.