MAZ (gene)

From Wikipedia, the free encyclopedia

MYC-associated zinc finger protein (purine-binding transcription factor)

Identifiers

MAZ; PUR1; Pur-1; SAF-1; SAF-2; ZF87; ZNF801; Zif87

External IDs

OMIM: 600999 MGI: 1338823 HomoloGene: 1787

Gene ontology
Molecular Function:	• nucleic acid binding • DNA binding • RNA polymerase II transcription factor activity • RNA binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • transcription termination from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001042539 (mRNA)
NP_001036004 (protein)

XM_001002765 (mRNA)
XP_001002765 (protein)

Location

Chr 16: 29.73 - 29.73 Mb

Chr 7: 126.81 - 126.82 Mb

Pubmed search

[1]

[2]

MYC-associated zinc finger protein (purine-binding transcription factor), also known as MAZ, is a human gene.^[1]

[edit] References

^ Entrez Gene: MAZ MYC-associated zinc finger protein (purine-binding transcription factor).

[edit] Further reading

Bossone SA, Asselin C, Patel AJ, Marcu KB (1992). "MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination.". Proc. Natl. Acad. Sci. U.S.A. 89 (16): 7452–6. PMID 1502157.
Pyrc JJ, Moberg KH, Hall DJ (1992). "Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter.". Biochemistry 31 (16): 4102–10. PMID 1567856.
Parks CL, Shenk T (1996). "The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1.". J. Biol. Chem. 271 (8): 4417–30. PMID 8626793.
Tsutsui H, Sakatsume O, Itakura K, Yokoyama KK (1996). "Members of the MAZ family: a novel cDNA clone for MAZ from human pancreatic islet cells.". Biochem. Biophys. Res. Commun. 226 (3): 801–9. doi:10.1006/bbrc.1996.1432. PMID 8831693.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Song J, Murakami H, Tsutsui H, et al. (1998). "Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ).". J. Biol. Chem. 273 (32): 20603–14. PMID 9685418.
Song J, Murakami H, Yang ZQ, et al. (1998). "Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2.". Genomics 52 (3): 374–7. doi:10.1006/geno.1998.5452. PMID 9790757.
Tsutsui H, Geltinger C, Murata T, et al. (1999). "The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II.". Biochem. Biophys. Res. Commun. 262 (1): 198–205. doi:10.1006/bbrc.1999.1130. PMID 10448092.
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
Jordan-Sciutto KL, Dragich JM, Caltagarone J, et al. (2000). "Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity.". Biochemistry 39 (12): 3206–15. PMID 10727212.
Ugai H, Li HO, Komatsu M, et al. (2001). "Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells.". Biochem. Biophys. Res. Commun. 286 (5): 1087–97. doi:10.1006/bbrc.2001.5469. PMID 11527412.
Ray BK, Murphy R, Ray P, Ray A (2003). "SAF-2, a splice variant of SAF-1, acts as a negative regulator of transcription.". J. Biol. Chem. 277 (48): 46822–30. doi:10.1074/jbc.M206299200. PMID 12270922.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bataller L, Wade DF, Graus F, et al. (2004). "The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction.". Ann. Neurol. 53 (1): 123–7. doi:10.1002/ana.10434. PMID 12509857.
Ray A, Kuroki K, Cook JL, et al. (2003). "Induction of matrix metalloproteinase 1 gene expression is regulated by inflammation-responsive transcription factor SAF-1 in osteoarthritis.". Arthritis Rheum. 48 (1): 134–45. doi:10.1002/art.10706. PMID 12528113.
Leroy C, Manen D, Rizzoli R, et al. (2005). "Functional importance of Myc-associated zinc finger protein for the human parathyroid hormone (PTH)/PTH-related peptide receptor-1 P2 promoter constitutive activity.". J. Mol. Endocrinol. 32 (1): 99–113. PMID 14765995.
Ray A, Shakya A, Kumar D, Ray BK (2004). "Overexpression of serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21WAF-1/Cip-1/Sdi-1 expression.". J. Immunol. 172 (8): 5006–15. PMID 15067082.
Ray BK, Shakya A, Turk JR, et al. (2005). "Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process.". Circ. Res. 95 (11): 1082–90. doi:10.1161/01.RES.0000150046.48115.80. PMID 15528467.
Gromak N, West S, Proudfoot NJ (2006). "Pause sites promote transcriptional termination of mammalian RNA polymerase II.". Mol. Cell. Biol. 26 (10): 3986–96. doi:10.1128/MCB.26.10.3986-3996.2006. PMID 16648491.
Ray A, Shakya A, Kumar D, et al. (2006). "Inflammation-responsive transcription factor SAF-1 activity is linked to the development of amyloid A amyloidosis.". J. Immunol. 177 (4): 2601–9. PMID 16888022.