May Hegglin anomaly
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| May Hegglin anomaly Classification and external resources |
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| ICD-10 | D72.0 |
|---|---|
| ICD-9 | 288.2 |
| OMIM | 155100 |
| DiseasesDB | 29517 |
| eMedicine | ped/1383 |
May Hegglin's anomaly, as it is also known, is a rare genetic disorder of the blood platelets that causes them to be abnormally large. Also, this anomaly causes abnormalities in the white blood cells known as leukocytes.
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[edit] Presentation
In the leukocytes, the presence of very small rods (around 3 micrometers), or Dohle bodies can be seen in the cytoplasm.
[edit] Treatment
In many cases, May Hegglin's requires no treatment. However, in extreme cases, blood platelet transfusions may be necessary
[edit] Causes
An association with MYH9 has been described.[1]
[edit] Eponym
It is named for Robert Hegglin and Richard May.[2][3][4]
[edit] References
- ^ Saito H, Kunishima S (2008). "Historical hematology: May-Hegglin anomaly". Am. J. Hematol. 83 (4): 304–6. doi:. PMID 17975807.
- ^ synd/113 at Who Named It
- ^ R. May. Leukocyteneinschlüsse. Kasuistische Mitteilung. Deutsches Archiv für klinische Medizin, Leipzig, 1909, 96: 1-6.
- ^ R. Hegglin. Über eine neue Form einer konstitutionellen Leukozytenanomalie, kombiniert mit Throbopathie. Schweizerische medizinische Wochenschrift, Basel, 1945, 75: 91-92.
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