Matrix metalloproteinase inhibitor
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A matrix metalloproteinase inhibitor (MMPI) inhibits matrix metalloproteinases. Since they inhibit cell migration they have antiangiogenic effects. They may be both endogenous and exogenous.
- The most notorious endogenous metalloproteinases are tissue inhibitor of metalloproteinases (TIMP). There are also cartilage-derived angiogenesis inhibitors.
- Exogenous matrix metalloproteinase inhibitors include batimastat and marimastat.
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