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Route 143 is a 25.4-mile, 40.88 kilometer west-east state highway in the U.S. state of Massachusetts. Its western terminus is at Route 8 in Hinsdale, at the town's center. Its eastern terminus is at Route 9 near the village of Searsville in Williamsburg. At Worthington, the highway is multiplexed with Route 112 for 0.8 miles (1.29 km), beginning at Worthington Corners. The road is also the only state route through the towns of Peru and Chesterfield, and also crosses the Westfield River in Chesterfield.