MAST2

From Wikipedia, the free encyclopedia

Microtubule associated serine/threonine kinase 2

Identifiers

MAST2; FLJ39200; KIAA0807; MAST205; MTSSK; RP4-533D7.1

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity • phosphatase binding
Cellular Component:	• cytoskeleton • membrane
Biological Process:	• protein amino acid phosphorylation • regulation of interleukin-12 biosynthetic process • spermatid differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015112 (mRNA)
NP_055927 (protein)

NM_001042743 (mRNA)
NP_001036208 (protein)

Location

Chr 1: 46.04 - 46.27 Mb

Chr 4: 115.8 - 115.96 Mb

Pubmed search

[1]

[2]

Microtubule associated serine/threonine kinase 2, also known as MAST2, is a human gene.^[1]

[edit] References

^ Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2.

[edit] Further reading

Walden PD, Cowan NJ (1994). "A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette.". Mol. Cell. Biol. 13 (12): 7625–35. PMID 8246979.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Walden PD, Millette CF (1997). "Increased activity associated with the MAST205 protein kinase complex during mammalian spermiogenesis.". Biol. Reprod. 55 (5): 1039–44. PMID 8902215.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452.
Lumeng C, Phelps S, Crawford GE, et al. (1999). "Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases.". Nat. Neurosci. 2 (7): 611–7. doi:10.1038/10165. PMID 10404183.
Adey NB, Huang L, Ormonde PA, et al. (2000). "Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding.". Cancer Res. 60 (1): 35–7. PMID 10646847.
Gisler SM, Stagljar I, Traebert M, et al. (2001). "Interaction of the type IIa Na/Pi cotransporter with PDZ proteins.". J. Biol. Chem. 276 (12): 9206–13. doi:10.1074/jbc.M008745200. PMID 11099500.
Okazaki N, Takahashi N, Kojima S, et al. (2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.". Carcinogenesis 23 (7): 1139–48. PMID 12117771.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.
Zhou H, Xiong H, Li H, et al. (2004). "Microtubule-associated serine/threonine kinase-205 kDa and Fc gamma receptor control IL-12 p40 synthesis and NF-kappa B activation.". J. Immunol. 172 (4): 2559–68. PMID 14764729.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Xiong H, Li H, Chen Y, et al. (2004). "Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability.". J. Biol. Chem. 279 (42): 43675–83. doi:10.1074/jbc.M404328200. PMID 15308666.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.