MAS1

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MAS1 oncogene
Identifiers
Symbol(s) MAS1; MAS; MGC119966
External IDs OMIM: 165180 MGI: 96918 HomoloGene: 1782
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4142 17171
Ensembl ENSG00000130368 ENSMUSG00000068037
Uniprot P04201 Q0VB49
Refseq NM_002377 (mRNA)
NP_002368 (protein)		 XM_622557 (mRNA)
XP_622557 (protein)
Location Chr 6: 160.25 - 160.25 Mb Chr 17: 12.68 - 12.69 Mb
Pubmed search [1] [2]

MAS1 oncogene, also known as MAS1, is a human gene.[1]

The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.[1]

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: MAS1 MAS1 oncogene.

[edit] Further reading

  • Hanley MR (1992). "Molecular and cell biology of angiotensin receptors.". J. Cardiovasc. Pharmacol. 18 Suppl 2: S7–13. PMID 1725048. 
  • Hanley MR, Cheung WT, Hawkins P, et al. (1990). "The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action.". Ciba Found. Symp. 150: 23–38; discussion 38–46. PMID 2197067. 
  • Rabin M, Birnbaum D, Young D, et al. (1988). "Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements.". Oncogene Res. 1 (2): 169–78. PMID 3329713. 
  • Jackson TR, Blair LA, Marshall J, et al. (1988). "The mas oncogene encodes an angiotensin receptor.". Nature 335 (6189): 437–40. doi:10.1038/335437a0. PMID 3419518. 
  • Young D, Waitches G, Birchmeier C, et al. (1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains.". Cell 45 (5): 711–9. PMID 3708691. 
  • Riesewijk AM, Schepens MT, Mariman EM, et al. (1996). "The MAS proto-oncogene is not imprinted in humans.". Genomics 35 (2): 380–2. doi:10.1006/geno.1996.0372. PMID 8661154. 
  • Xu X, Quiambao AB, Roveri L, et al. (2000). "Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene.". Exp. Neurol. 163 (1): 207–19. doi:10.1006/exnr.2000.7370. PMID 10785460. 
  • Alenina N, Baranova T, Smirnow E, et al. (2002). "Cell type-specific expression of the Mas proto-oncogene in testis.". J. Histochem. Cytochem. 50 (5): 691–6. PMID 11967280. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Santos RA, Simoes e Silva AC, Maric C, et al. (2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8258–63. doi:10.1073/pnas.1432869100. PMID 12829792. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Canals M, Jenkins L, Kellett E, Milligan G (2006). "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS.". J. Biol. Chem. 281 (24): 16757–67. doi:10.1074/jbc.M601121200. PMID 16611642. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened