MARS (gene)

From Wikipedia, the free encyclopedia

Methionyl-tRNA synthetase

PDB rendering based on 2djv.

Available structures: 2djv

Identifiers

Symbol(s)

MARS; FLJ35667; METRS; MTRNS

External IDs

OMIM: 156560 MGI: 1345633 HomoloGene: 3656

Gene ontology
Molecular Function:	• tRNA binding • nucleotide binding • methionine-tRNA ligase activity • ATP binding • ligase activity
Cellular Component:	• soluble fraction • cytoplasm
Biological Process:	• methionyl-tRNA aminoacylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004990 (mRNA)
NP_004981 (protein)

NM_001003913 (mRNA)
NP_001003913 (protein)

Location

Chr 12: 56.17 - 56.2 Mb

Chr 10: 126.7 - 126.71 Mb

Pubmed search

[1]

[2]

Methionyl-tRNA synthetase, also known as MARS, is a human gene.^[1]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene belongs to the class I family of tRNA synthetases.^[1]

[edit] References

^ ^a ^b Entrez Gene: MARS methionyl-tRNA synthetase.

[edit] Further reading

Norcum MT (1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents.". J. Biol. Chem. 266 (23): 15398-405. PMID 1651330.
Ogata K, Kurahashi A, Kenmochi N, Terao K (1992). "Role of 5SrRNA as a positive effector of some aminoacyl-tRNA synthetases in macromolecular complexes, with specific reference to methionyl-tRNA synthetase.". J. Biochem. 110 (6): 1037-44. PMID 1665486.
Cirullo RE, Wasmuth JJ (1984). "Assignment of the human MARS gene, encoding methioninyl-tRNA synthetase, to chromosome 12 using human X Chinese hamster cell hybrids.". Somat. Cell Mol. Genet. 10 (3): 225-34. PMID 6585969.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Lage H, Dietel M (1996). "Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase.". Gene 178 (1-2): 187-9. PMID 8921912.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Quevillon S, Robinson JC, Berthonneau E, et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein.". J. Mol. Biol. 285 (1): 183-95. doi:10.1006/jmbi.1998.2316. PMID 9878398.
Ubeda M, Schmitt-Ney M, Ferrer J, Habener JF (1999). "CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability.". Biochem. Biophys. Res. Commun. 262 (1): 31-8. doi:10.1006/bbrc.1999.1140. PMID 10448063.
Ko YG, Kang YS, Kim EK, et al. (2000). "Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis.". J. Cell Biol. 149 (3): 567-74. PMID 10791971.
Kang J, Kim T, Ko YG, et al. (2000). "Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases.". J. Biol. Chem. 275 (41): 31682-8. doi:10.1074/jbc.M909965199. PMID 10913161.
Kaminska M, Shalak V, Mirande M (2002). "The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function.". Biochemistry 40 (47): 14309-16. PMID 11714285.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ahn HC, Kim S, Lee BJ (2003). "Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43.". FEBS Lett. 542 (1-3): 119-24. PMID 12729910.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.