MAP kinase kinase kinase

From Wikipedia, the free encyclopedia

MAP kinase activation
Mitogen
↓
MAP kinase kinase kinase

(MAP3K or MKKK)
↓
MAP kinase kinase

(MAP2K or MKK)
↓
MAP kinase
↓
further signalling

MAP kinase kinase kinase (or MAP3K or MEKK) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase.

There are 15 genes:

MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4).[1] MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway.[2] MAP3K7(TAK1)participate in regulation of transcription by transforming growth factor-beta (TGF-beta).[3]

[edit] External links

[edit] References

  1. ^ Yan M, et al. (1994). "Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1". Nature 372: 798–800. 
  2. ^ Ellinger-Ziegelbauer H, et al. (1997). "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative". J Biol Chem. 272: 2668–74. doi:10.1074/jbc.272.5.2668. 
  3. ^ Yamaguchi K, et al. (1995). "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction". Science 270: 2008–11. doi:10.1126/science.270.5244.2008. 
 This biochemistry article is a stub. You can help Wikipedia by expanding it.
v • d • e
Kinases: Serine/threonine-specific protein kinases (primarily EC 2.7.11)
2.7.11
2.7.12
MAP2K (1, 2, 3, 4, 5, 6, 7)
2.7.1.37, or unknown