MAPRE3

From Wikipedia, the free encyclopedia

Microtubule-associated protein, RP/EB family, member 3

PDB rendering based on 1wyo.

Available structures: 1wyo

Identifiers

Symbol(s)

MAPRE3; RP3; EB3; EBF3; EBF3-S

External IDs

OMIM: 605788 MGI: 2140967 HomoloGene: 56565

Gene ontology
Molecular Function:	• small GTPase regulator activity • microtubule binding
Cellular Component:	• cellular_component • microtubule
Biological Process:	• cell cycle • mitosis • biological_process • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012326 (mRNA)
NP_036458 (protein)

NM_133350 (mRNA)
NP_579928 (protein)

Location

Chr 2: 27.05 - 27.1 Mb

Chr 5: 31.09 - 31.14 Mb

Pubmed search

[1]

[2]

Microtubule-associated protein, RP/EB family, member 3, also known as MAPRE3, is a human gene.^[1]

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAPRE3 microtubule-associated protein, RP/EB family, member 3.

[edit] Further reading

Renner C, Pfitzenmeier JP, Gerlach K, et al. (1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells.". J. Immunol. 159 (3): 1276–83. PMID 9233623.
Juwana JP, Henderikx P, Mischo A, et al. (1999). "EB/RP gene family encodes tubulin binding proteins.". Int. J. Cancer 81 (2): 275–84. PMID 10188731.
Nakagawa H, Koyama K, Murata Y, et al. (2000). "EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue.". Oncogene 19 (2): 210–6. doi:10.1038/sj.onc.1203308. PMID 10644998.
Su LK, Qi Y (2001). "Characterization of human MAPRE genes and their proteins.". Genomics 71 (2): 142–9. doi:10.1006/geno.2000.6428. PMID 11161807.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bu W, Su LK (2004). "Characterization of functional domains of human EB1 family proteins.". J. Biol. Chem. 278 (50): 49721–31. doi:10.1074/jbc.M306194200. PMID 14514668.
Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMID 15631994.
Yeh TY, Chuang JZ, Sung CH (2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway.". J. Cell. Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.