MAPRE2

From Wikipedia, the free encyclopedia

Microtubule-associated protein, RP/EB family, member 2

Identifiers

MAPRE2; RP1; EB1; EB2

External IDs

OMIM: 605789 MGI: 106271 HomoloGene: 75027

Gene ontology
Molecular Function:	• microtubule binding
Cellular Component:	• microtubule
Biological Process:	• cellular defense response • cell cycle • mitosis • signal transduction • cell proliferation • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014268 (mRNA)
NP_055083 (protein)

NM_153058 (mRNA)
NP_694698 (protein)

Location

Chr 18: 30.88 - 30.98 Mb

Chr 18: 23.95 - 24.04 Mb

Pubmed search

[1]

[2]

Microtubule-associated protein, RP/EB family, member 2, also known as MAPRE2, is a human gene.^[1]

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAPRE2 microtubule-associated protein, RP/EB family, member 2.

[edit] Further reading

Tirnauer JS, Bierer BE (2000). "EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability.". J. Cell Biol. 149 (4): 761–6. PMID 10811817.
Su LK, Burrell M, Hill DE, et al. (1995). "APC binds to the novel protein EB1.". Cancer Res. 55 (14): 2972–7. PMID 7606712.
Renner C, Pfitzenmeier JP, Gerlach K, et al. (1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells.". J. Immunol. 159 (3): 1276–83. PMID 9233623.
Berrueta L, Kraeft SK, Tirnauer JS, et al. (1998). "The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10596–601. PMID 9724749.
Morrison EE, Wardleworth BN, Askham JM, et al. (1999). "EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle.". Oncogene 17 (26): 3471–7. doi:10.1038/sj.onc.1202247. PMID 10030671.
Juwana JP, Henderikx P, Mischo A, et al. (1999). "EB/RP gene family encodes tubulin binding proteins.". Int. J. Cancer 81 (2): 275–84. PMID 10188731.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Nakamura M, Zhou XZ, Lu KP (2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization.". Curr. Biol. 11 (13): 1062–7. PMID 11470413.
Askham JM, Vaughan KT, Goodson HV, Morrison EE (2003). "Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome.". Mol. Biol. Cell 13 (10): 3627–45. doi:10.1091/mbc.E02-01-0061. PMID 12388762.
Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ (2003). "EB1 targets to kinetochores with attached, polymerizing microtubules.". Mol. Biol. Cell 13 (12): 4308–16. doi:10.1091/mbc.E02-04-0236. PMID 12475954.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bu W, Su LK (2004). "Characterization of functional domains of human EB1 family proteins.". J. Biol. Chem. 278 (50): 49721–31. doi:10.1074/jbc.M306194200. PMID 14514668.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMID 15631994.
Xu H, Hebert MD (2006). "A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin.". BMC Cell Biol. 6 (1): 23. doi:10.1186/1471-2121-6-23. PMID 15862129.
Wang Y, Zhou X, Zhu H, et al. (2005). "Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway.". Oncogene 24 (44): 6637–45. doi:10.1038/sj.onc.1208819. PMID 16007168.