MAPK8

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Mitogen-activated protein kinase 8
PDB rendering based on 1jnk.
Available structures: 1jnk, 1pmn, 1pmq, 1pmu, 1pmv, 1ukh, 1uki, 2b1p, 2exc, 2g01, 2gmx, 2h96, 2no3, 2o0u, 2o2u, 2ok1
Identifiers
Symbol(s)	MAPK8; JNK; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1
External IDs	OMIM: 601158 MGI: 1346861 HomoloGene: 56760
Gene ontology Molecular Function: • nucleotide binding • protein serine/threonine kinase activity • JUN kinase activity • MAP kinase activity • protein binding • ATP binding • transferase activity Biological Process: • ossification • protein amino acid phosphorylation • cell motility • response to stress • signal transduction • JNK cascade
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	5599	26419
Ensembl	ENSG00000107643	ENSMUSG00000021936
Uniprot	P45983	Q544A0
Refseq	NM_002750 (mRNA) NP_002741 (protein)	NM_016700 (mRNA) NP_057909 (protein)
Location	Chr 10: 49.18 - 49.32 Mb	Chr 14: 32.21 - 32.28 Mb
Pubmed search	[1]	[2]

Mitogen-activated protein kinase 8, also known as MAPK8, is a human gene.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.^[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Kinases: Serine/threonine-specific protein kinases (primarily EC 2.7.11) 2.7.11 Pyruvate dehydrogenase kinase - Protein kinase A - Protein kinase G Protein kinase C (Protein kinase Mζ) G-protein coupled receptor kinases (Rhodopsin, Beta adrenergic receptor) Ca2+/calmodulin-dependent (Elongation factor 2 kinase, Myosin light-chain) Phosphorylase - Cyclin-dependent Mitogen-activated (Extracellular signal-regulated, C-Jun N-terminal (MAPK8, MAPK9), P38 mitogen-activated protein) MAP3K - GSK-3 - AMP-activated 2.7.12 MAP2K (1, 2, 3, 4, 5, 6, 7) 2.7.1.37, or unknown Anti-Mullerian hormone receptor - Ataxia telangiectasia mutated - Aurora (A, B) - Mammalian target of rapamycin - Bone morphogenetic protein receptors (1, 2) - CDKL5 - c-Raf - EIF-2 - Ribosomal s6 - Protein kinase B - PDK1