MAPK8IP2

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase 8 interacting protein 2

Identifiers

MAPK8IP2; IB2; JIP2; PRKM8IPL

External IDs

OMIM: 607755 MGI: 1926555 HomoloGene: 8201

Gene ontology
Molecular Function:	• beta-amyloid binding • MAP-kinase scaffold activity • structural molecule activity • kinesin binding • protein kinase binding
Cellular Component:	• cytoplasm • cell soma
Biological Process:	• signal complex assembly • positive regulation of anti-apoptosis • regulation of JNK cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_139124 (mRNA)
NP_621713 (protein)

NM_021921 (mRNA)
NP_068740 (protein)

Location

Chr 22: 49.39 - 49.4 Mb

Chr 15: 89.28 - 89.29 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase 8 interacting protein 2, also known as MAPK8IP2, is a human gene.^[1]

The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Yasuda J, Whitmarsh AJ, Cavanagh J, et al. (2000). "The JIP group of mitogen-activated protein kinase scaffold proteins.". Mol. Cell. Biol. 19 (10): 7245–54. PMID 10490659.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.". Mol. Cell. Biol. 20 (3): 1030–43. PMID 10629060.
Negri S, Oberson A, Steinmann M, et al. (2000). "cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein.". Genomics 64 (3): 324–30. doi:10.1006/geno.2000.6129. PMID 10756100.
Gotthardt M, Trommsdorff M, Nevitt MF, et al. (2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.". J. Biol. Chem. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
Schoorlemmer J, Goldfarb M (2001). "Fibroblast growth factor homologous factors are intracellular signaling proteins.". Curr. Biol. 11 (10): 793–7. PMID 11378392.
Taru H, Kirino Y, Suzuki T (2002). "Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism.". J. Biol. Chem. 277 (30): 27567–74. doi:10.1074/jbc.M203713200. PMID 12023290.
Buchsbaum RJ, Connolly BA, Feig LA (2002). "Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade.". Mol. Cell. Biol. 22 (12): 4073–85. PMID 12024021.
Schoorlemmer J, Goldfarb M (2003). "Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase.". J. Biol. Chem. 277 (51): 49111–9. doi:10.1074/jbc.M205520200. PMID 12244047.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Willoughby EA, Perkins GR, Collins MK, Whitmarsh AJ (2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK.". J. Biol. Chem. 278 (12): 10731–6. doi:10.1074/jbc.M207324200. PMID 12524447.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22.". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMID 12529303.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kristensen O, Guenat S, Dar I, et al. (2006). "A unique set of SH3-SH3 interactions controls IB1 homodimerization.". EMBO J. 25 (4): 785–97. doi:10.1038/sj.emboj.7600982. PMID 16456539.