MAPK4

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase 4

Identifiers

MAPK4; ERK3; Erk4; PRKM4; p63MAPK

External IDs

OMIM: 176949 MGI: 2444559 HomoloGene: 2058

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • MAP kinase activity • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation • cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002747 (mRNA)
NP_002738 (protein)

NM_172632 (mRNA)
NP_766220 (protein)

Location

Chr 18: 46.34 - 46.51 Mb

Chr 18: 74.05 - 74.19 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase 4, also known as MAPK4, is a human gene.^[1]

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.^[1]

[edit] References

^ ^a ^b Entrez Gene: MAPK4 mitogen-activated protein kinase 4.

[edit] Further reading

Seger R, Krebs EG (1995). "The MAPK signaling cascade.". FASEB J. 9 (9): 726–35. PMID 7601337.
Davis RJ (1996). "Transcriptional regulation by MAP kinases.". Mol. Reprod. Dev. 42 (4): 459–67. doi:10.1002/mrd.1080420414. PMID 8607977.
Robinson MJ, Cobb MH (1997). "Mitogen-activated protein kinase pathways.". Curr. Opin. Cell Biol. 9 (2): 180–6. PMID 9069255.
Gonzalez FA, Raden DL, Rigby MR, Davis RJ (1992). "Heterogeneous expression of four MAP kinase isoforms in human tissues.". FEBS Lett. 304 (2-3): 170–8. PMID 1319925.
Zhu AX, Zhao Y, Moller DE, Flier JS (1994). "Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.". Mol. Cell. Biol. 14 (12): 8202–11. PMID 7969157.
Li L, Wysk M, Gonzalez FA, Davis RJ (1994). "Genomic loci of human mitogen-activated protein kinases.". Oncogene 9 (2): 647–9. PMID 8290275.
Kinet S, Bernard F, Mongellaz C, et al. (2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes.". Blood 100 (7): 2546–53. doi:10.1182/blood-2002-03-0819. PMID 12239168.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sun M, Wei Y, Yao L, et al. (2006). "Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3.". Biochem. Biophys. Res. Commun. 340 (1): 209–14. doi:10.1016/j.bbrc.2005.12.003. PMID 16360641.
Kant S, Schumacher S, Singh MK, et al. (2007). "Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5.". J. Biol. Chem. 281 (46): 35511–9. doi:10.1074/jbc.M606693200. PMID 16973613.