MAPK3

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Main article: Extracellular signal-regulated kinases

Mitogen-activated protein kinase 3
Identifiers
Symbol(s)	MAPK3; ERK1; HS44KDAP; HUMKER1A; MGC20180; P44ERK1; P44MAPK; PRKM3
External IDs	OMIM: 601795 MGI: 1346859 HomoloGene: 55682
Gene ontology Molecular Function: • nucleotide binding • phosphotyrosine binding • protein kinase activity • protein serine/threonine kinase activity • MAP kinase activity • protein binding • ATP binding • transferase activity Cellular Component: • cellular_component • nucleus • cytoplasm Biological Process: • regulation of progression through cell cycle • protein amino acid phosphorylation • response to DNA damage stimulus • cell cycle • organ morphogenesis • sensory perception of pain
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	5595	26417
Ensembl	ENSG00000102882	ENSMUSG00000063065
Uniprot	P27361	Q63844
Refseq	NM_001040056 (mRNA) NP_001035145 (protein)	NM_011952 (mRNA) NP_036082 (protein)
Location	Chr 16: 30.03 - 30.04 Mb	Chr 7: 126.55 - 126.56 Mb
Pubmed search	[1]	[2]

Mitogen-activated protein kinase 3, also known as MAPK3, is a human gene.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.^[1]

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