MAPK1

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It has been suggested that this article or section be merged with Extracellular signal-regulated kinases#Mitogen-activated protein kinase 1. (Discuss)

Main article: Extracellular signal-regulated kinases

Mitogen-activated protein kinase 1, also known as MAPK1, is a human gene.

Mitogen-activated protein kinase 1

PDB rendering based on 1erk.

Available structures: 1erk, 1gol, 1pme, 1tvo, 1wzy, 2erk, 2fys, 2gph, 2ojg, 2oji, 2ojj, 3erk, 4erk

Identifiers

Symbol(s)

MAPK1; p38; ERK; p40; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p41; p41mapk

External IDs

OMIM: 176948 MGI: 1346858 HomoloGene: 37670

Gene ontology
Molecular Function:	• nucleotide binding • phosphotyrosine binding • protein serine/threonine kinase activity • MAP kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• MAPKKK cascade • protein amino acid phosphorylation • induction of apoptosis • chemotaxis • response to DNA damage stimulus • cell cycle • signal transduction • synaptic transmission • organ morphogenesis • cytosine metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002745 (mRNA)
NP_002736 (protein)

NM_001038663 (mRNA)
NP_001033752 (protein)

Location

Chr 22: 20.45 - 20.55 Mb

Chr 16: 16.9 - 16.96 Mb

Pubmed search

[1]

[2]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.^[1]

[edit] References

^ Entrez Gene: MAPK1 mitogen-activated protein kinase 1.

[edit] Further reading

Morishima-Kawashima M, Hasegawa M, Takio K, et al. (1995). "Hyperphosphorylation of tau in PHF.". Neurobiol. Aging 16 (3): 365–71; discussion 371–80. PMID 7566346.
Davis RJ (1996). "Transcriptional regulation by MAP kinases.". Mol. Reprod. Dev. 42 (4): 459–67. doi:10.1002/mrd.1080420414. PMID 8607977.
Peruzzi F, Gordon J, Darbinian N, Amini S (2003). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway.". J. Neurovirol. 8 Suppl 2: 91–6. doi:10.1080/13550280290167885. PMID 12491158.
Greenway AL, Holloway G, McPhee DA, et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.". J. Biosci. 28 (3): 323–35. PMID 12734410.
Meloche S, Pouysségur J (2007). "The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition.". Oncogene 26 (22): 3227–39. doi:10.1038/sj.onc.1210414. PMID 17496918.