MAPK15

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase 15

Identifiers

MAPK15; ERK7; ERK8

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • MAP kinase activity • ATP binding • transferase activity • SH3 domain binding
Cellular Component:	• extracellular region • intracellular
Biological Process:	• protein amino acid autophosphorylation

Orthologs

Human

Mouse

Refseq

NM_139021 (mRNA)
NP_620590 (protein)

XM_994652 (mRNA)
XP_999746 (protein)

Location

Chr 8: 144.87 - 144.88 Mb

Chr 15: 75.82 - 75.83 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase 15, also known as MAPK15, is a human gene.^[1]

[edit] References

^ Entrez Gene: MAPK15 mitogen-activated protein kinase 15.

[edit] Further reading

Saelzler MP, Spackman CC, Liu Y, et al. (2006). "ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5.". J. Biol. Chem. 281 (24): 16821-32. doi:10.1074/jbc.M512418200. PMID 16624805.
Iavarone C, Acunzo M, Carlomagno F, et al. (2006). "Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.". J. Biol. Chem. 281 (15): 10567-76. doi:10.1074/jbc.M513397200. PMID 16484222.
Klevernic IV, Stafford MJ, Morrice N, et al. (2006). "Characterization of the reversible phosphorylation and activation of ERK8.". Biochem. J. 394 (Pt 1): 365-73. doi:10.1042/BJ20051288. PMID 16336213.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kinet S, Bernard F, Mongellaz C, et al. (2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes.". Blood 100 (7): 2546-53. doi:10.1182/blood-2002-03-0819. PMID 12239168.
Abe MK, Saelzler MP, Espinosa R, et al. (2002). "ERK8, a new member of the mitogen-activated protein kinase family.". J. Biol. Chem. 277 (19): 16733-43. doi:10.1074/jbc.M112483200. PMID 11875070.
Qian Z, Okuhara D, Abe MK, Rosner MR (1999). "Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel.". J. Biol. Chem. 274 (3): 1621-7. PMID 9880541.