MAPK14

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Mitogen-activated protein kinase 14
PDB rendering based on 1a9u.
Available structures: 1a9u, 1bl6, 1bl7, 1bmk, 1di9, 1ian, 1kv1, 1kv2, 1lew, 1lez, 1m7q, 1ouk, 1ouy, 1ove, 1oz1, 1p38, 1r39, 1r3c, 1w7h, 1w82, 1w83, 1w84, 1wbn, 1wbo, 1wbs, 1wbt, 1wbv, 1wbw, 1wfc, 1yqj, 1yw2, 1ywr, 1zyj, 1zz2, 1zzl, 2baj, 2bak, 2bal, 2baq, 2ewa, 2fsl, 2fsm, 2fso, 2fst, 2gfs, 2ghl, 2ghm, 2gtm, 2gtn, 2i0h, 2okr, 2onl, 2oza
Identifiers
Symbol(s)	MAPK14; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA
External IDs	OMIM: 600289 MGI: 1346865 HomoloGene: 31777
Gene ontology Molecular Function: • nucleotide binding • protein serine/threonine kinase activity • MAP kinase activity • MAP kinase kinase activity • protein binding • ATP binding • MP kinase activity • transferase activity Cellular Component: • spindle pole • cell • nucleus • cytoplasm Biological Process: • DNA damage checkpoint • angiogenesis • glucose metabolic process • protein amino acid phosphorylation • cell motility • chemotaxis • response to stress • cell surface receptor linked signal transduction • protein kinase cascade • striated muscle development • fatty acid oxidation • antimicrobial humoral response • positive regulation of erythrocyte differentiation • positive regulation of transcription from RNA polymerase II promoter
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1432	26416
Ensembl	ENSG00000112062	ENSMUSG00000053436
Uniprot	Q16539	P47811
Refseq	NM_001315 (mRNA) NP_001306 (protein)	NM_011951 (mRNA) NP_036081 (protein)
Location	Chr 6: 36.1 - 36.19 Mb	Chr 17: 28.42 - 28.48 Mb
Pubmed search	[1]	[2]

Main article: P38 mitogen-activated protein kinases

Mitogen-activated protein kinase 14, also known as MAPK14, is a human gene.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.^[1]

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